Project description:Activation of hepatic NF-kB signaling induces inflammation and ultimately fibrosis. To investigate the underlying mechanism, we used microarrays to detail the global programme of gene expression which is regulated by hepatic NF-kB signaling. We generated transgenic mice which express a constitutively active IKK2 controlled under the LAP promotor. The liver samples were collected from transgenic mice as well as from control animals at the age of 4 weeks. RNA extraction was performed from these liver samples and hybridized on Affymetrix microarrays.
Project description:Transcription profiling by array of embryonic mouse heart ventricles with and without cardiomycocyte-specific expression of constitutively active IKK2
Project description:To investigate gene expression changes associated with Eya3 knockdown and add-back of constitutively-active NF-kB (IKK2-SE) in 66cl4 cells
