Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: RNA-Seq anlalysis of prostate cancer cell lines using Next Generation Sequencing

OTHER RELATED OMICS DATASETS IN: phs000597.v1.p1GSE27619

PROVIDER: PRJNA142987 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR202054.fastq.gz	Fastqsanger.gz
	SRR202055.fastq.gz	Fastqsanger.gz
	SRR202056.fastq.gz	Fastqsanger.gz
	SRR202057.fastq.gz	Fastqsanger.gz
	SRR202058.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 13

Similar Datasets

Homo sapiens

Project description:DNA methylation analysis of prostate cancer cell lines and tissues using Next Generation Sequencing

| PRJNA141775 | ENA

Homo sapiens

Project description:Discovery of Non-ETS Gene Fusions in Human Prostate Cancer using Next Generation RNA Sequencing

| PRJNA74907 | ENA

Homo sapiens

Project description:Identification of MELK-regulated genes in prostate cancer cells using next-generation sequencing

| PRJNA371482 | ENA

Homo sapiens

Project description:Next generation sequencing to determine alternative cleavage and polyadenylation events among prostate and prostate cancer cell lines

| PRJNA340467 | ENA

Homo sapiens

Project description:Immunoprofiling of gastric cancer using next-generation sequencing data.

| PRJDB8985 | ENA

RNA-Seq anlalysis of prostate cancer cell lines using Next Generation Sequencing

Project description:Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in selected prostate tissues and cell lines using Methylplex-Next Generation Sequencing (M-NGS). Hidden Markov Model based next generation sequence analysis identified ~68,000 methylated regions per sample. While global CpG Island (CGI) methylation was not differential between benign adjacent and cancer samples, overall promoter CGI methylation increased from ~12.6% in benign samples to 19.3% and 21.8% in localized and metastatic cancer tissues, respectively. We found distinct patterns of promoter methylation around transcription start sites, where methylation occurred not only on the CGIs, but also on flanking regions and CGI sparse promoters. Among the 6,691 methylated promoters in prostate tissues, 2481 differentially methylated regions (DMRs) are cancer specific, including numerous novel DMRs. A novel cancer specific DMR in WFDC2 promoter showed heavy methylation in cancer (17/22 tissues, 6/6 cell lines), but not in the benign tissues (0/10) and normal PrEC cells. Integration of LNCaP DNA methylation and H3K4me3 data suggested an epigenetic mechanism for alternate transcription start site utilization and these modifications segregated into distinct regions when present on the same promoter. Finally, we observed differences in repeat element methylation, particularly LINE-1, between ERG gene fusion positive and negative cancers. This comprehensive methylome map will further our understanding of epigenetic regulation in prostate cancer progression. Next generation Sequencing for Gene expression using the RNA-Seq methodology from LNCaP and PrEC cell lines

2011-05-09 | E-GEOD-29155 | biostudies-arrayexpress

Homo sapiens

Project description:Next Generation Sequencing of total RNA from 9 bladder cancer cell lines and 3 fractionated bladder cancer cell lines

| PRJNA393566 | ENA

Homo sapiens whole blood.

Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

2019-07-31 | GSE114179 | GEO

Homo sapiens Transcriptome or Gene expression

Project description:Asthma is a chronic inflammatory airway disease characterized by airway inflammation and remodeling. The role of 15-oxo-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-oxoETE), a 15-HETE metabolite catalyzed by 15-prostaglandin dehydrogenase (15-PGDH), has been relatively unexplored in asthma. In this study, we used RNA-seq to explore the effect of 15-KETE on the transcriptome of airway epithelial cells, aiming to identify its potential downstream targets and mechanisms of action.

2026-05-21 | GSE325003 | GEO

Homo sapiens

Project description:Next generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy

| PRJNA219507 | ENA