Ontology highlight
ABSTRACT:
PROVIDER: PRJNA144255 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:DNA samples of haploid ES cells and control DNA were compared to genomic DNA of the C57B/6 inbred mouse strain on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9), (GPL10989) DNA samples of haploid ES cells and control DNA were compared to genomic DNA of the 129/Sv inbred mouse strain on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9), (GPL10989)
2011-07-23 | GSE30749 | GEO
Project description:This SuperSeries is composed of the following subset Series: GSE30744: Expression analysis of haploid and diploid ES cells in 2i medium GSE30749: CGH analysis of haploid ES cells Refer to individual Series
2011-07-22 | E-GEOD-30879 | biostudies-arrayexpress
Project description:Expression analysis of eu-miR-155 transgenic mice B-cells.
2014-10-10 | E-GEOD-30248 | ExpressionAtlas
Project description:Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise only as post-meiotic germ cells that serve to insure a diploid genome upon fertilization. Gamete manipulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but as of yet not from humans. Here we analyzed a large collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading to the successful isolation and maintenance of human ES cell lines with a normal haploid karyotype. Haploid human ES cells exhibited typical pluripotent stem cell characteristics such as self-renewal capacity and a pluripotency-specific molecular signature. Although haploid human ES cells resembled their diploid counterparts, they also displayed distinct properties including differential regulation of X chromosome inactivation and genes involved in oxidative phosphorylation, alongside reduction in absolute gene expression levels and cell size. Intriguingly, we found that a haploid genome is compatible not only with the undifferentiated pluripotent state, but also with differentiated somatic fates representing all three embryonic germ layers, despite a persistent dosage imbalance between the autosomes and X chromosome. We expect that haploid human ES cells will provide novel means for studying human functional genomics, development and evolution.
2016-03-16 | GSE74950 | GEO
Project description:DNA samples of haploid ES cells and control DNA were compared to genomic DNA of the C57B/6 inbred mouse strain on a NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9), (GPL10989) this analysis was performed to analyse copy number variations in haploid mouse ES cells from different genetic backgrounds. Male C57/B6 DNA was used as control. To identify CNVs based on the different genetic background control experiments comparing DNA from the inbred CBA and a mixed transgeneic mouse strain were performed.
2011-07-22 | E-GEOD-30749 | biostudies-arrayexpress
Project description:Gene expression analysis of Wnt+ and Wnt- effector CD8 T cells
2015-07-31 | E-GEOD-53358 | ExpressionAtlas
Project description:Gene expression analysis of SDH-deficient immortalized mouse kidney epithelial cells
2016-02-03 | E-MTAB-4349 | ExpressionAtlas
Project description:RNA-Seq CAGE (Cap Analysis of Gene Expression) analysis of mice cells in RIKEN FANTOM5 project
2015-06-04 | E-MTAB-3578 | ExpressionAtlas
Project description:CGH analysis of androgenetic haploid embryonic stem cells
| PRJNA170766 | ENA