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Homo sapiens

ABSTRACT: Analysis of the RNA-Seq data of castration resistant prostate cancer (CRPCa)

PROVIDER: PRJNA145521 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR332266_1.fastq.gz	Fastqsanger.gz
	SRR332266_2.fastq.gz	Fastqsanger.gz
	SRR332267_1.fastq.gz	Fastqsanger.gz
	SRR332267_2.fastq.gz	Fastqsanger.gz
	SRR332268_1.fastq.gz	Fastqsanger.gz

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Project description:To identify molecular singnal alterations between androgen dependent prostate cancer and castration resistant prostate cancer, we performed interspecies comparative microarray analyses using RNAs prepared from uncastrasion and castration tumor from LNCAP Orhotopic xenograft models of prostate cancer. microarray data from uncastrasion and castration tumor revealed that the gene expression profile is most significantly altered in between androgen dependent prostate cancer and castration resistant prostate cancer. Comparative analyses of LNCAP Orhotopic xenograft models of prostate cancer showed that genes involved in androgen dependent and androgen independent tumor were significantly altered. We prepared RNA samples from 4 samples uncastrasion and 4 samples castration tumors from LNCAP Orhotopic xenograft models of prostate cancer . High-quality RNA samples were subjected to microarray analysis using the Affymetrix Human Gene 2.0 ST platform, and only those results that passed examinations for quality assurance and quality control of the Human Gene 2.0 ST arrays were retrieved. In total, we obtained gene expression profiles from the following samples: 4 samples uncastrasion and 4 samples castration tumors

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Project description:<p>Biopsies of castration resistant prostate cancer metastases were subjected to whole genome sequencing (WGS), along with RNA-sequencing (RNA-Seq). The overarching goal of the study is to illuminate molecular mechanisms of acquired resistance to therapeutic agents, and particularly androgen signaling inhibitors, in the treatment of metastatic castration resistant prostate cancer (mCRPC).</p>

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