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Gallus gallus

ABSTRACT: microRNA profiling in Marek's disease virus induced lymphoma and infected spleen by deep sequencing

PROVIDER: PRJNA145935 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR332252.fastq.gz	Fastqsanger.gz
	SRR332253.fastq.gz	Fastqsanger.gz
	SRR332254.fastq.gz	Fastqsanger.gz
	SRR332255.fastq.gz	Fastqsanger.gz

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microRNA profiling in Marek's disease virus induced lymphoma and infected spleen by deep sequencing

Project description:To investigate specific miRNA expression profiles of Marek's disease virus (MDV)-infected samples, we performed deep sequencing for miRNAs in four small RNA libraries, including MDV-infected tumorous spleen, MD lymphoma from liver, and non-infected spleen and lymphocytes from controls. A total of 7.76x106, 6.36x106, 6.36x106, and 7.60x106 counts were obtained in four libraries, respectively. The sequences were blasted with chicken and MDV genomes and miRBase 16.0 to identify known and novel miRNAs. In total, 187 and 16 known mature miRNAs were identified in the chicken and MDV, respectively. Deep sequencing detected 942 novel chicken miRNA candidates, of which 646 were in tumorous spleen. These results indicate that MDV infection induced new host miRNA candidates and increased diversity of miRNAs. Of 942 miRNA candidates, 276 of 533 were verified by customized microarray, and 17 of them were further confirmed by qPCR. Four samples examined: MDV-infected tumorous spleen, MD lymphoma from liver, Non-infected spleen, Non-infected lymphocytes

2013-12-30 | E-GEOD-31349 | biostudies-arrayexpress

microRNA profiling in Marek's disease virus induced lymphoma and infected spleen by deep sequencing

2013-12-30 | GSE31349 | GEO

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Project description:Gene expression analysis of host spleen responses to Marek's disease virus infection in susceptible and resistant chickens

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Chicken Spleen Tissues: MDV-infected vs non-infected in inbred lines 63, 72 & RCSM

Project description:Transcriptional profiling of chicken spleen tissues from Marek's disease virus (MDV) infected and non-infected control individuals from three inbred chicken lines 63, 72, RCSM with varying disease resistance characteristics. Line 63 is highly resistant; line 72 is highly susceptible; and line RCSM has intermediate resistance. Our goal was to investigate the genetic basis of systemic variation in disease resistance in these genetically similar individuals. Three time points were chosen at different stages of disease progression - 5 days post-infection (dpi) - early cytolytic phase; 10 dpi - latent phase; and 21 dpi - late cytolytic phase with 4 replicates at each stage.

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Single cell RNA-seq of spleens of chickens from Marek's-disease-resistant and -susceptible lines infected with Marek's disease virus

Project description:We infected chickens from two genetic lines, one bred to be resistant to Marek's disease and one bred to be susceptible, with the Marek's disease virus. We performed single-cell RNA sequencing of the spleens of these chickens along with age-matched uninfected controls from both lines.

2022-09-16 | E-MTAB-12145 | biostudies-arrayexpress

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Project description:Whole Genome Sequencing of Marek's Disease Lymphoma Gonadal Tumors and Matched Normal Tissues

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Chicken Spleen Tissues: MDV-infected vs non-infected in inbred lines 63, 72 & RCSM

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Genome-wide studies of microRNAs in Marek's tumorigenesis in Chicken (miRNA-Seq)

Project description:Marek's disease (MD), induced by Marek's disease virus (MDV), is a lymphotropic neoplastic disease and causes huge economic losses to the poultry industry. Non-coding RNAs play important regulatory roles in disease pathogenesis. To investigate host miRNA expression profile, RNA sequencing was performed in tumorous spleens (TS), spleens from the survivors (SS) without any lesion after MDV infection, and noninfected chicken spleens (NS).

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