Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Danio rerio

ABSTRACT: Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis

PROVIDER: PRJNA147789 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR352241.fastq.gz	Fastqsanger.gz
	SRR352242.fastq.gz	Fastqsanger.gz
	SRR352243.fastq.gz	Fastqsanger.gz
	SRR352244.fastq.gz	Fastqsanger.gz
	SRR352245.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Danio rerio

Project description:N6-methyladenosine dynamics during early vertebrate embryogenesis

| PRJNA353372 | ENA

Danio rerio

Project description:Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis

| PRJNA325807 | ENA

Danio rerio

Project description:mRNA structure dynamics identifies RNA remodelers and functional elements during embryogenesis: mRNA-seq

| PRJNA473824 | ENA

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [ChIP-Seq]

Project description:Since its discovered, the dynamics and molecular regulation of bivalent chromatin during early embryogenesis remain poorly understood. We trace gene expression and bivalent chromatin dynamics in peri-implantation mouse embryogenesis, showing bifurcated establishment in epiblast and primitive endoderm. We identify transiently maintained bivalent domains (TB domains) in the epiblast, crucial for pluripotency progression. Our study reveals 22 candidate factors, including ZBTB17, essential for resolving TB domains and activating pluripotency regulators. These dynamics are conserved in human pluripotent transition.

2025-07-24 | GSE274494 | GEO

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [CUT&Tag]

2025-07-24 | GSE274493 | GEO

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Valid RNA-Seq]

2025-07-24 | GSE274492 | GEO

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Wild type RNA-Seq]

2025-07-24 | GSE274490 | GEO

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [hESC valid]

2025-07-24 | GSE297673 | GEO

The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [mESC valid]

2025-07-24 | GSE297849 | GEO

1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis

Project description:The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specification and cell lineage differentiation, advancing the study of human embryonic development and the translation of innovations in drug discovery, disease modelling and cell-based therapies. The metabolic regulation of IPSC pluripotency is mediated by balancing glycolysis and oxidative phosphorylation, but there is a paucity of data regarding the influence of individual metabolite changes during cell lineage differentiation. We used <sup>1</sup>H NMR metabolite fingerprinting and footprinting to monitor metabolite levels as IPSCs are directed in a three-stage protocol through primitive streak/mesendoderm, mesoderm and chondrogenic populations. Metabolite changes were associated with central metabolism, with aerobic glycolysis predominant in IPSC, elevated oxidative phosphorylation during differentiation and fatty acid oxidation and ketone body use in chondrogenic cells. Metabolites were also implicated in the epigenetic regulation of pluripotency, cell signalling and biosynthetic pathways. Our results show that <sup>1</sup>H NMR metabolomics is an effective tool for monitoring metabolite changes during the differentiation of pluripotent cells with implications on optimising media and environmental parameters for the study of embryogenesis and translational applications.

2023-05-24 | MTBLS4854 | MetaboLights

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data