Arabidopsis thaliana
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA151793 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Five members of the Arabidopsis thaliana NF-YA gene family are strongly induced by several stress conditions via transcriptional and miR169-related posttranscriptional mechanisms. These transcription factors participate in gene regulation via two different mechanisms, one depending on binding to the CCAAT-box in the promoter of regulated genes and the other, independent of the CCAAT-box, in which NF-YA prevents the interaction of the NF-YB/YC heterodimer with transcription factors.
2012-04-25 | GSE36092 | GEO
Project description:Five members of the Arabidopsis thaliana NF-YA gene family are strongly induced by several stress conditions via transcriptional and miR169-related posttranscriptional mechanisms. These transcription factors participate in gene regulation via two different mechanisms, one depending on binding to the CCAAT-box in the promoter of regulated genes and the other, independent of the CCAAT-box, in which NF-YA prevents the interaction of the NF-YB/YC heterodimer with transcription factors. Three biological and two technical (in swap) replicates for each genotype were obtained for each treatment (DMSO (mock) and estradiol 24h after induction). Mock samples were pooled and used as a reference.
2012-04-24 | E-GEOD-36092 | biostudies-arrayexpress
Project description:Nuclear Factor Y (NF-Y) is a heterotrimeric transcription factor that binds CCAAT elements. The NF-Y trimer is composed of a Histone Fold Domain (HFD) dimer (NF-YB/NF-YC) and NF-YA, which confers DNA sequence specificity. NF-YA shares a conserved domain with the CONSTANS, CONSTANS-LIKE, TOC1 (CCT) proteins. We show that CONSTANS (CO/B-BOX PROTEIN1 BBX1), a master flowering regulator, forms a trimer with Arabidopsis thaliana NF-YB2/NF-YC3 to efficiently bind the CORE element of the FLOWERING LOCUS T promoter. Using saturation mutagenesis, electrophoretic mobility shift assays, and RNA-sequencing profiling of co, nf-yb, and nf-yc mutants, we identify CCACA elements as the core NF-CO binding site. CO physically interacts with the same HFD surface required for NF-YA association, as determined by mutations in NF-YB2 and NF-YC9, and tested in vitro and in vivo. The co-7 mutation in the CCT domain, corresponding to an NF-YA arginine directly involved in CCAAT recognition, abolishes NF-CO binding to DNA
2022-06-09 | GSE205675 | GEO
Project description:The transcription factor NF-Y promotes cell proliferation and often loses its activity during differentiation through the regulation of NF-YA, the DNA binding subunit of the complex. In stem cell compartments, the shorter NF-YA splice variant (NF-YAs) is abundantly expressed and sustains their expansion. Here, we report that satellite cells, the stem cell population of adult skeletal muscle necessary for its growth and regeneration, express uniquely the longer NF-YA isoform (NF-YAl), majorly associated with cell differentiation. Through the generation of a conditional knock out mouse model that selectively ablates NF-YA in satellite cells, we demonstrate that NF-YA expression, and hence NF-Y activity, is fundamental to preserve the pool of muscle stem cells. Moreover, NF-Y supports their commitment to differentiation and ensures robust regenerative response to muscle injury. Gene expression profiling highlights an unexpected role for NF-Y in stem cell biology and opens a new scenario for NF-Y activity that is dispensable for muscle stem cell proliferation but required for efficient myogenic differentiation.
2021-08-30 | GSE154017 | GEO
Project description:shRNA knockdown of the transcription factor NF-YA (NFYA)
| PRJNA173230 | ENA
Project description:Arabidopsis lyrata scaffold_600636.1, CCAAT-binding transcription factor (CBF-B/NF-YA) family protein [Source:UniProtKB/TrEMBL;Acc:D7LZR1], is expressed in 1 baseline experiment(s);
| scaffold_600636.1 | ExpressionAtlas
Project description:Orchestration of development by the bifunctional transcription factor, APETALA2
| PRJNA126567 | ENA
Project description:The polarization and activation of macrophages are controlled synergistically by transcription factors such as NF-κB and AP-1 transcription factor members. Surprisingly, little is known about the role of the Fra proteins, both members of the AP-1 transcription factor family, in macrophage activity. To determine the full profile of Fra network, microarray RNA expression analysis using Agilent Technologies platform was performed in wild-type, Fra-1ΔMxCre or Fra-2ΔLysMCre macrophages.
2021-05-17 | GSE128787 | GEO
Project description:Arabidopsis lyrata fgenesh2_kg.1__3232__AT1G30500.2, CCAAT-binding transcription factor (CBF-B/NF-YA) family protein [Source:UniProtKB/TrEMBL;Acc:D7KFK5], is expressed in 1 baseline experiment(s);
| fgenesh2_kg.1__3232__AT1G30500.2 | ExpressionAtlas
Project description:Arabidopsis lyrata fgenesh2_kg.4__1496__AT2G34720.1, CCAAT-binding transcription factor (CBF-B/NF-YA) family protein [Source:UniProtKB/TrEMBL;Acc:D7LH39], is expressed in 1 baseline experiment(s);
| fgenesh2_kg.4__1496__AT2G34720.1 | ExpressionAtlas