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Mus musculus

ABSTRACT: DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors

PROVIDER: PRJNA154447 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR350282.fastq.gz	Fastqsanger.gz
	SRR350283.fastq.gz	Fastqsanger.gz
	SRR350284.fastq.gz	Fastqsanger.gz
	SRR350285.fastq.gz	Fastqsanger.gz
	SRR350286.fastq.gz	Fastqsanger.gz

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Gene expression and DNA methylation of lung tumors in Dnmt3a deficient vs. WT mice

Project description:This SuperSeries is composed of the following subset Series: GSE32415: Mouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT GSE32484: DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors Refer to individual Series

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DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors

Project description:To examine whether Dnmt3a deficiency resulted in genomic methylation changes we performed an unbiased methylome analysis. Methylated DNA isolated from three Dnmt3a deficient and two WT tumors was immunoprecipitated and subjected to high throughput sequencing (MeDIP-Seq). We observed that genes that were less expressed in Dnmt3a deficient tumors tended to have lower methylation levels in gene bodies.

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DNA methylation of dnmt3a deficient Kras lung tumors and dnmt3a wt Kras lung tumors

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Project description:Gene expression and DNA methylation of lung tumors in Dnmt3a deficient vs. WT mice

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Project description:Mouse lung tumor tissue: Dnmt3a KO vs. Dnmt3a WT

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Disruption of STAT3 signaling promotes KRAS induced lung tumorigenesis

Project description:Oncogenic STAT3 functions are known in various malignancies. We found that STAT3 plays an unexpected tumor suppressive role in KRAS-mutant non-small-cell-lung cancer (NSCLC). In mice, tissue-specific inactivation of Stat3 resulted in increased Kras (G12D)-driven NSCLC initiation and malignant progression leading to markedly reduced survival. Clinically, low STAT3 expression levels correlate with poor survival in human lung adenocarcinoma patients with smoking history. Consistently, KRAS-mutant lung tumors showed reduced STAT3 levels. Mechanistically, we show that STAT3 controls NFÎºB-induced IL-8-expression by sequestering NFÎºB in the cytoplasm while IL-8 in turn regulates myeloid tumor infiltration and tumor vascularization thereby promoting tumor progression. These results identify a novel STAT3-NFÎºB-IL-8 axis in KRAS-mutant NSCLC with therapeutic and prognostic relevance WT: Control lung; KRAS: Lung tumors expressing KRAS G12D; KRAS STAT3 KO: Lung tumors expressing KRAS G12D- STAT3 deficient; tumors of four mice pooled per sample

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Dnmt3a protects active chromosome domains against cancer-associated hypomethylation

Project description:The results of the study uncover conserved features of cancer methylomes and provide a mechanistic explanation for the tumor-promoting effects of Dnmt3a mutations. Whole genome methylation analysis of Mus musculus. Five samples were analyzed, one control sample containing normal healthy lung tissue, two samples containing big (WTB) or small (WTS) Dnmt3a WT tumors, two samples containing big (KOB) or small (KOS) Dnmt3a knock-out tumors

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