Project description:Genome-wide case-control association study in Sweden, with the aim to study the genetic basis of schizophrenia risk, disease severity and treatment resistance, as well as the interplay with environmental risk factors. The study cohort includes array-based data from whole blood-DNA. Population-based sampling was used to recruit cases with schizophrenia, based on data from the Swedish national patient register, as well as controls who had never been hospitalized for schizophrenia or bipolar disorder.
Project description:<p>Current findings of the genetic risk of schizophrenia and bipolar disorder emerging from genome wide association studies (GWAS) support a highly polygenic model displaying the full spectrum of causal alleles that includes the extremes of rare, penetrant alleles as well as common alleles of small effect. Lower frequency polymorphism, rare variants and private mutations have eluded measurement by GWAS studies and thus association with disease. In order to create a comprehensive catalogue of low frequency or rare coding variation in individuals with psychiatric disease and to build a foundation for future genetic studies of schizophrenia and bipolar disorder, we have obtained whole exome DNA sequence from a population-based schizophrenia and bipolar disorder Swedish case-control cohort.</p>
Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
