Project description:Reticular dysgenesis (RD) is a human Severe Combined Immunodeficiency mainly characterized by a profound neutropenia and lymphopenia. This pathology is due to mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of AK2 protein expression. AK2 is a mitochondrial protein, which regulates the homeostasis of cellular adenine nucleotides by converting ADP into ATP and AMP. Using a RNA interference strategy, we dissected the role of AK2 during the commitment of hematopoietic progenitors towards the lymphoid or myeloid lineage. Our results demonstrated that AK2 knock-down progenitors have reduced proliferative and survival capacity and differentiation toward the lymphoid or granulocytic lineage is abrogated. In this report, we also highlighted that AK2 signaling pathway is essential to control energy production and to maintain the integrity of all mitochondrial functions. This steady state may be disturbed in RD patients leading to a blockade of the differentiation process.

2015-06-21 | E-MTAB-2680 | biostudies-arrayexpress

Pontivivens nitratireducens strain:ALG8

Project description:Pontivivens nitratireducens strain:ALG8 Genome sequencing

| PRJNA610143 | ENA

Desulfurivibrio nitratireducens strain:C05AmB

Project description:Desulfurivibrio nitratireducens strain:C05AmB Genome sequencing

| PRJNA1175670 | ENA

Marinilabilia salmonicolor

Project description:Marinilabilia salmonicolor overview

| PRJNA158241 | ENA

Pontivivens nitratireducens strain:h42

Project description:Pontivivens nitratireducens strain:h42 Genome sequencing and assembly