Project description:We reported transcriptome profiles of rifamycin SV-produced strain Amycolatopsis mediterranei U32 in the Bennet medium with or without 80 mM nitrate in different cultivation stage. By comparative analysis of genome-wide gene expression in these conditions, we found that the mechanism of high production of rifamycin SV induced by nitrate could be elucidated.
Project description:Bulk RNA sequencing was performed on BJ human fibroblasts transfected with control siRNA or FH-targeting siRNA to investigate transcriptomic changes associated with FH silencing. Four biological replicates per condition were analyzed.
