Adenoviridae
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA16846 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Virion: large, enveloped Genome: non segmented, linear, double-stranded DNA
| PRJNA16974 | ENA
Project description:Survey of single and double stranded DNA non-enveloped viruses on the skin of WHIM patients, healthy controls and other immune compromised patients
| PRJNA396064 | ENA
Project description:Cancer cachexia has been linked to gut bacterial alterations, but alterations of gut viruses, mostly bacteriophages, have not yet been explored. We performed shotgun metagenomic sequencing of DNA from stool samples of 78 cachectic and 42 non-cachectic cancer patients. K-mer-based matching to reference databases revealed abundance variations of bacteria and viruses. Beyond bacterial alterations, cachectic patients exhibited significantly lower bacteriophage abundance, predominantly affecting Caudovirales and Siphoviridae species (double-stranded DNA) but also Inoviridae and Microviridae families (single-stranded DNA).
| EGAS00001007156 | EGA
Project description:LL-37, a 37-amino acid human-derived antimicrobial peptide, exhibits antiviral functions against multiple enveloped and non-enveloped viruses. We here report that the expression of the Stac is upregulated by LL-37 regardless of EV71 infection in Caco-2 colorectal adenocarcinoma cells. The treatment of LL-37 inhibits viral infection compared to the scramble(scr) control. In addition, LL-37 significantly upregulates the Stac expression in the presence or absence of EV71 infection, while the viral infection itself does not affect the expression of Stac. Take together, our data provide a novel mechanism of its antiviral activity for non-enveloped viruses, in which LL-37 modulates the host genes, interfering with the process of viral infection.
2026-05-14 | GSE311775 | GEO
Project description:Hepatitis B virus (HBV) is an enveloped, coated, non-cytopathic and hepatotropic partially double-stranded DNA virus in the family Hepadnaviridae genus Orthohepadnavirus. Despite significant progress in the availability of safe vaccines and antiviral therapies against HBV, it still affects approximately 257 million people worldwide and is responsible for about 887,000 deaths per year around the world [4]. HBV infection, which are associated with acute and chronic liver failure responses to viruses attacked the liver, can result in inactive carrier state, chronic hepatitis, or fulminant hepatitis and put them at high risk to develop advanced liver fibrosis and cirrhosis, and even hepatocellular cancer. Many viral factors, which could affect the disparity of clinical outcomes or disease prognosis during chronic HBV infection, have been reported in previous studies; among them, the viral genotype, as well as HBV mutations ascribing the virus to a certain phenotype, was reported to be the most important factor influencing viral pathogenesis, including the change of host immune recognition, the enhanced virulence with increased HBV replication and the facilitation of cell attachment or penetration.
2022-02-17 | PXD025968 | Pride
Project description:Iridoviridae family giant double-stranded DNA viruses from the South Atlantic
| PRJEB48731 | ENA
Project description:Iridoviridae family giant double-stranded DNA viruses from the South Atlantic
| PRJEB48732 | ENA
Project description:Hepatoviruses, a common cause of acute hepatitis in humans, are atypical picornaviruses released from cells in small vesicles resembling exosomes. We show the nonlytic release of these quasi-enveloped virions is mediated by a C-terminal extension of the VP1 capsid protein (pX) that binds the Bro1 domains of ALIX and HD-PTP, and recruits the ubiquitin ligase ITCH to drive an association with endosomal sorting complexes required for transport (ESCRT). Fusing pX to a self-assembling, de novo designed nanocage protein resulted in ESCRT-dependent release mediated by a 20-amino acid core sequence containing a Y[KR]xxR[LM] motif conserved in viruses from bats to humans. Mutations in this motif ablate release and lead virus to accumulate intracellularly. Our study identifies an exceptionally potent viral export signal mediating extracellular release of virus-sized protein assemblies, identifies its key cellular binding partners, and shows non-lytic release of quasi-enveloped virus is a tightly orchestrated and ancient evolutionary trait of hepatoviruses.
2022-08-02 | PXD022107 | Pride