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Drosophila melanogaster

ABSTRACT: Chromatin proteins linked to dosage compensation in Drosophila captured by ChIP-mass spectrometry

PROVIDER: PRJNA178936 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR611192.fastq.gz	Fastqsanger.gz
	SRR611193.fastq.gz	Fastqsanger.gz
	SRR611194.fastq.gz	Fastqsanger.gz
	SRR611195.fastq.gz	Fastqsanger.gz
	SRR611196.fastq.gz	Fastqsanger.gz

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Chromatin proteins linked to dosage compensation in Drosophila captured by ChIP-mass spectrometry

Project description:We report the usage of ChIP-mass spectrometry in identifying proteins and histone modifications involved in Drosophila dosage compensation. We identified a chromatin targeting factor, CG4747, that is involved in recognition of H3K36me3 and robust recruitment of the Drosophila MSL complex to its correct targets on the male X chromosome.

2012-11-06 | GSE42025 | GEO

Chromatin proteins linked to dosage compensation in Drosophila captured by ChIP-mass spectrometry

2012-11-06 | E-GEOD-42025 | biostudies-arrayexpress

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Targeting of the dosage-compensated male X-chromosome during early Drosophila development

Project description:The essential process of dosage compensation, which corrects for the imbalance in X-linked gene expression between XX females and XY males, represents a key model for how genes are targeted for coordinated regulation. However, the mechanism by which dosage compensation complexes identify the X-chromosome during early development remained unknown because of the difficulty of sexing embryos prior to zygotic transcription. We used meiotic drive to sex Drosophila embryos prior to zygotic transcription and ChIP-seq to measure dynamics of dosage compensation factor targeting. The Drosophila Male-Specific Lethal dosage compensation complex (MSLc) requires the ubiquitous zinc-finger protein Chromatin-Linked Adaptor for MSL Proteins (CLAMP) to identify the X-chromosome. We observe a multi-stage process in which MSLc first identifies CLAMP binding sites throughout the genome followed by concentration at the strongest X-linked MSLc sites. We provide insight into the dynamic mechanism by which a large transcription complex identifies its binding sites during early development.

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H4K16ac and RNAPol2 CUT&Tag of Drosophila Melanogaster and Bacillus Grandii

Project description:This experiment was designed to investigate the epigenetic basis of sex chromosome dosage compensation. Such mechanisms often operate through epigenetic modifications, including histone modifications, which alter chromatin structure and gene expression. In Drosophila melanogaster, dosage compensation is achieved by upregulating the single X chromosome in males through acetylation of histone H4 at lysine 16 (H4K16ac). We therefore used D. melanogaster as a positive control to validate our approach. In contrast, the mechanism of dosage compensation in Bacillus grandii remains unknown. By profiling H4K16ac in this species, we aim to test whether this histone modification may have been convergently recruited to mediate dosage compensation.

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Drosophila melanogaster

Project description:Synergistic interactions between CLAMP and MSL complex facilitate Drosophila dosage compensation

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Project description:Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP

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Drosophila melanogaster

Project description:Chromosomal High Affinity Binding Sites for the Drosophila Dosage Compensation Complex.

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Sex-dependent and -independent X-chromosome histone modifications in Drosophila melanogaster

Project description:Drosophila X chromosomes are subject to dosage compensation in males and are known to have a specialized chromatin structure in the male soma. We are interested in how specific chromatin structure change contributes to X chromosome hyperactivity and dosage compensation. We have conducted a global analysis of localize two dosage compensation complex dependent histone marks H4AcK16 and H3PS10 and one dosage compensation complex independent histone mark H3diMeK4 in the genome, especially on X chromosome by ChIP-chip approach in both male and female adult flies. We also probed general genomewide chromatin structure by deep DNA sequencing of sheared ChIP input DNA from male and female adult flies.

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