Project description:This study investigates transcriptomic responses of Pacific salmon lice, Lepeophtheirus salmonis, to infection with the microsporidian Facilispora margolisi and/or exposure to emamectin benzoate (EMB), an antiparasitic agent commonly used in salmon aquaculture.
Project description:LC-MS/MS data of metabolites produced by Streptomyces baldaccii NRRL B-3500 grown in monoculture (ISP2, A-medium, and RAM2) and grasshopper-associated conditions.
The dataset includes monoculture extracts, grasshopper-associated samples (+GH), grasshopper controls without bacteria (BLK+GH), and methanol extracts prepared with (YW) or without (NW) aqueous pretreatment.
Data were acquired using an Agilent 6550 iFunnel Q-TOF LC/MS system.
Project description:Microsporidia are intracellular eukaryotic pathogens that pose a substantial threat to immunocompromised hosts. The way these pathogens manipulate host cells during infection remains poorly understood. Using a proximity biotinylation strategy we established that microsporidian EnP1 is a nucleus-targeted effector that modifies the host cell environment. EnP1's translocation to the host nucleus is meditated by nuclear localization signals (NLSs). In the nucleus, EnP1 interacts with host histone H2B. This interaction disrupts H2B monoubiquitination (H2Bub), subsequently impacting p53 expression. Crucially, this inhibition of p53 weakens its control over the downstream target gene SLC7A11, enhancing the host cell's resilience against ferroptosis during microsporidian infection. This favorable condition promotes the proliferation of microsporidia within the host cell. These findings shed light on the molecular mechanisms by which microsporidia modify their host cells to facilitate their survival.
2023-11-21 | GSE247835 | GEO
Project description:Grasshopper genome skimming
| PRJNA806454 | ENA
Project description:Aquatic microsporidian and eukaryotic diversity
