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Mus musculus

ABSTRACT: Role of Retinoids x Receptor and Retinoic Acid Receptor in Mouse Liver

OTHER RELATED OMICS DATASETS IN: E-GEOD-50028

PROVIDER: PRJNA202289 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR848077.fastq.gz	Fastqsanger.gz
	SRR848078.fastq.gz	Fastqsanger.gz
	SRR954825.fastq.gz	Fastqsanger.gz

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Role of Retinoids x Receptor and Retinoic Acid Receptor in Mouse Liver

Project description:Genome-wide binding of Retinoids x Receptor and Retinoic Acid Receptor in mouse liver was described

2013-05-15 | GSE46762 | GEO

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Project description:Cistrome profiles of Retinoids x Receptor alpha (RXRα) , Retinoic Acid Receptor alpha (RARα), and Retinoic Acid Receptor beta (RARβ) in livers of mice treated by control and retionic acid-containing diet

| PRJNA232748 | ENA

Role of Retinoids x Receptor in Mouse Liver

Project description:Genome-wide binding of Retinoids x Receptor in mouse liver was described Using ChIP-Seq data to clarify the role of RXRa in liver

2013-05-15 | E-GEOD-46762 | biostudies-arrayexpress

Gene expression data of untreated and RA-treated wild type and RXRÎ±-deficient mice liver

Project description:Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR. So we treated the wild type and RXRÎ±-knockout mice by retinoic acid to check the global gene expression especially for lipid homeostasis genes. We used microarrays to observe the global gene expression underlying hepatic lipid homeostasis. We treated both the wild type and RXRÎ±-KO mice with normal diet and RA-containing diet for 7 days. For each group, three replicates were done. Liver total RNA were used to test global gene expression by microarray.

2013-08-21 | E-GEOD-50028 | biostudies-arrayexpress

Study on the Effects of Retinoids on UVR-Induced Skin Photoaging [RNA-seq]

Project description:Photoaging contributes to up to 80% of visible facial aging signs, making it a major dermatological concern. While retinoids such as retinol and all-trans retinoic acid (ATRA) promote extracellular matrix (ECM) regeneration, their side effects limit widespread use. We propose that hydroxypinacolone 9-cis retinoate (9-cis HPR), a derivative of 9-cis retinoic acid, activates both retinoic acid receptor (RAR) and retinoid X receptor (RXR), enhancing efficacy while minimizing irritation. However, its in vivo anti-photoaging effects remain underexplored. This study evaluates 9-cis HPR in the UVR-damaged SKH-1 mouse model, investigating its role in inflammation control, ECM regeneration, and melanogenesis suppression.

2026-01-20 | GSE294121 | GEO

Study on the Effects of Retinoids on UVR-Induced Skin Photoaging [Spatial Transcriptomics]

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Study on the Effects of Retinoids on UVR-Induced Skin Photoaging [scRNA-seq]

2026-01-20 | GSE294119 | GEO

Gene expression data of untreated and RA-treated wild type and RXRα-deficient mice liver

Project description:Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR. So we treated the wild type and RXRα-knockout mice by retinoic acid to check the global gene expression especially for lipid homeostasis genes. We used microarrays to observe the global gene expression underlying hepatic lipid homeostasis.

2013-08-21 | GSE50028 | GEO

Transcriptional profile of human breast cancer MCF7 cells and clones thereof expressing human ERβ1 or ERβ2 upon treatment with antiestrogens and retinoids.

Project description:The aim of the experiment was to gain insight into the role of estrogen receptor beta (ERβ) isoforms in the response of breast cancer MCF7 cells to antiestrogens and retinoids. To this end, clones of MCF7 cells constitutively expressing human ERβ1 (MCF7-ERβ1) or ERβ2 (MCF7-ERβ2) were established and used for the determination of the global transcriptional changes induced upon treatment with hydroxytamoxifen (OHT) and all-trans retinoic acid (ATRA). Gene signatures associated with each clone will shed light to the mechanism underlying the ERβ1- and ERβ2-mediated response of MCF7 cells to antiestrogens and retinoids.

2022-12-13 | E-MTAB-12549 | biostudies-arrayexpress

Effects of retinoids on estrogen-receptor-positive and -negative breast carcinoma cells: mRNA profiling

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