Project description:The actin cytoskeleton is a highly conserved structural network that supports diverse cellular processes, but its contribution to organismal aging is not well understood. This project investigates how genetic and pharmacological perturbations of actin and actin-binding proteins influence global gene expression and aging phenotypes in Caenorhabditis elegans. Whole-animal RNA interference was used to knock down key actin regulatory genes, including arx-2 (Arp2/3 complex), unc-60 (cofilin), and lev-11 (tropomyosin). Here single-nucleus RNA sequencing was performed to assess transcriptional responses to actin cytoskeletal disruption across tissues and age groups (Day 1 and Day 5). These datasets capture transcriptomic signatures associated with actin dysfunction, aging trajectories, and stress responses, and provide a resource for exploring the molecular links between cytoskeletal integrity and longevity regulation.

2026-05-07 | E-MTAB-16195 | biostudies-arrayexpress

NHLBI SNP Health Association Resource (SHARe) Project

Project description:NHLBI SNP Health Association Resource (SHARe) Projects, genome-wide association studies in NHLBI cohorts

| PRJNA51455 | ENA

Mutant Mouse Regional Resource Center (MMRRC) Research

Project description:This study is part of the Mutant Mouse Regional Resource Center Research. The series subsets represent the strain and age group for easy comparisons. Each subseries has data for three different tissues (brain, liver and kidney) and 2 sexes. Keywords: other

2005-10-18 | E-GEOD-1920 | biostudies-arrayexpress

Homo sapiens

Project description:Resource for Genetic Epidemiology Research in Adult Health and Aging (“GERA”)

| PRJNA226740 | ENA

Mutant Mouse Regional Resource Center (MMRRC) Research

2005-10-18 | GSE1920 | GEO

Joint Addiction, Aging, and Mental Health Data Access Committee General Research Use Datasets

Project description:Joint Addiction, Aging, and Mental Health Data Access Committee General Research Use Datasets

| PRJNA934661 | ENA