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Homo sapiens

ABSTRACT: Fusion discovery in breast cancer cell line

PROVIDER: PRJNA229558 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1035700_1.fastq.gz	Fastqsanger.gz
	SRR1035700_2.fastq.gz	Fastqsanger.gz
	SRR1035701_1.fastq.gz	Fastqsanger.gz
	SRR1035701_2.fastq.gz	Fastqsanger.gz
	SRR1035702_1.fastq.gz	Fastqsanger.gz

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Project description:In this study, we characterize the fusion protein produced by the EPC1-PHF1 translocation in Low Grade Endometrial Stromal Sarcoma (LG-ESS) and Ossifying FibroMyxoid Tumors (OFMT). We express the fusion protein and necessary controls in K562 Cells. The fusion protein assembles a mega-complex harboring both NuA4/TIP60 and PRC2 subunits and enzymatic activities and leads to mislocalization of chromatin marks in the genome, linked to aberrant gene expression.

2020-11-25 | GSE162118 | GEO