Project description:The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. This study was designed to establish a preclinical model of resistance to induction therapy in childhood T-ALL to examine the emergence of drug resistance and identify novel therapies. We performed transcription profiling by array of human CD45-positive human lymphocytes from patients with acute pediatric lymphoblastic leukemia, and from xenografted NOD/SCID mice treated with vincristine, daunorubicin, dexamethasone and L-asparagine. Several different treatment regimes were used in this study (VLXD, VLXDR, VLXD2, VXL and VLXD2-ALL31) and are summarised in the protocols associated with this submission.

2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress

Homo sapiens

Project description:Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

| PRJNA214597 | ENA

Homo sapiens

Project description:Genome-wide differential gene expression signatures in pediatric acute lymphoblastic leukemia subtypes

| PRJNA203378 | ENA

Homo sapiens

Project description:RNA-seq of Hyperdiploid Pediatric Acute Lymphoblastic Leukemia

| PRJNA171806 | ENA

Homo sapiens

Project description:Down's syndrome with acute lymphoblastic pediatric leukemia (DS-ALL)

| PRJNA118735 | ENA

Homo sapiens

Project description:MLLT10 gene recombinations in pediatric T-Acute Lymphoblastic Leukemia

| PRJNA183087 | ENA

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