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Caenorhabditis elegans

ABSTRACT: PID-1 is a novel factor that operates during 21U RNA biogenesis in Caenorhabditis elegans

PROVIDER: PRJNA239266 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1175720.fastq.gz	Fastqsanger.gz
	SRR1175711.fastq.gz	Fastqsanger.gz
	SRR1175721.fastq.gz	Fastqsanger.gz
	SRR1175712.fastq.gz	Fastqsanger.gz
	SRR1175722.fastq.gz	Fastqsanger.gz

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Caenorhabditis elegans

Project description:MicroRNA-Directed siRNA Biogenesis in Caenorhabditis elegans

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PID-1 is a novel factor that operates during 21U RNA biogenesis in Caenorhabditis elegans

Project description:Animal germ cells employ small RNA-based mechanisms to recognize and silence DNA that invades their genome. One of these pathways is named the Piwi:piRNA pathway. Biogenesis of piRNAs is poorly understood. In C. elegans, the piRNA (21U-RNA)-binding Argonaute protein PRG-1 is the only known player acting downstream of pre-cursor transcription. From a screen aimed at the isolation of M-bM-^@M-^XpiRNA-induced silencing defectiveM-bM-^@M-^Y mutations we identified, amongst known Piwi-pathway components like MUT-7, RDE-3 and HRDE-1, PID-1 as a novel player. PID-1 is essential for 21U RNA biogenesis and affects an early step in the processing or transport of 21U precursor transcripts. 12 small RNA samples were analyzed as singletons.

2014-03-17 | E-GEOD-55309 | biostudies-arrayexpress

PID-1 is a novel factor that operates during 21U RNA biogenesis in Caenorhabditis elegans

Project description:Animal germ cells employ small RNA-based mechanisms to recognize and silence DNA that invades their genome. One of these pathways is named the Piwi:piRNA pathway. Biogenesis of piRNAs is poorly understood. In C. elegans, the piRNA (21U-RNA)-binding Argonaute protein PRG-1 is the only known player acting downstream of pre-cursor transcription. From a screen aimed at the isolation of ‘piRNA-induced silencing defective’ mutations we identified, amongst known Piwi-pathway components like MUT-7, RDE-3 and HRDE-1, PID-1 as a novel player. PID-1 is essential for 21U RNA biogenesis and affects an early step in the processing or transport of 21U precursor transcripts.

2014-03-17 | GSE55309 | GEO

Caenorhabditis elegans

Project description:Caenorhabditis elegans

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