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Homo sapiens

ABSTRACT: Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

OTHER RELATED OMICS DATASETS IN: E-GEOD-56087

PROVIDER: PRJNA242387 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR1200850_1.fastq.gz	Fastqsanger.gz
	SRR1200850_2.fastq.gz	Fastqsanger.gz
	SRR1200860_1.fastq.gz	Fastqsanger.gz
	SRR1200860_2.fastq.gz	Fastqsanger.gz
	SRR1200870_1.fastq.gz	Fastqsanger.gz

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E-GEOD-56087

Project description:Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

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Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

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Dosage compensation mass spectrometry in platypus, chicken and mouse

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Project description:In mammals, X-chromosomal genes are expressed from a single copy since males (XY) possess a single X chromosome, while females (XX) undergo X inactivation. To compensate for this reduction in dosage compared to two active copies of autosomes, it has been proposed that genes from the active X chromosome exhibit dosage compensation. However, the existence and mechanism of X-to-autosome dosage compensation are still under debate. Here, we show that X-chromosomal transcripts are reduced in m6A modifications and more stable compared to their autosomal counterparts. Acute depletion of m6A selectively stabilises autosomal transcripts, resulting in perturbed dosage compensation in mouse embryonic stem cells. We propose that higher stability of X-chromosomal transcripts is directed by lower levels of m6A, indicating that mammalian dosage compensation is partly regulated by epitranscriptomic RNA modifications.

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