Project description:Most Cellulomonas strains are cellulolytic and this feature may be applied in straw degradation and bioremediation. In this study, Cellulomonas carbonis T26(T), Cellulomonas bogoriensis DSM 16987(T) and Cellulomonas cellasea 20108(T) were sequenced. Here we described the draft genomic information of C. carbonis T26(T) and compared it to the related Cellulomonas genomes. Strain T26(T) has a 3,990,666 bp genome size with a G + C content of 73.4 %, containing 3418 protein-coding genes and 59 RNA genes. The results showed good correlation between the genotypes and the physiological phenotypes. The information are useful for the better application of the Cellulomonas strains.
Project description:This study investigates the transcriptional changes in murine colon adenocarcinoma MC38 cells in response to treatment with T26, a novel compound designed to modulate glutamine metabolism and immune-related pathways. RNA sequencing (RNA-Seq) was performed to compare the transcriptomic profiles of MC38 cells treated with T26 versus untreated controls. Differentially expressed genes were analyzed to elucidate the molecular mechanisms underlying T26-mediated anti-tumor activity. This dataset provides a resource for understanding how T26 impacts tumor cell-intrinsic gene expression and may inform its potential role in cancer immunotherapy.
