Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA243616 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:This study evaluates genetic and phenotypic variation in the intermediate altitude Calchaquí population living in the Calchaquí Valleys of the Argentinean Andes in the town of Cachi at 2300 m. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to moderate hypoxia at a intermediate altitude.
2014-04-05 | GSE56518 | GEO
Project description:This study evaluates genetic and phenotypic variation in the intermediate altitude Calchaquà population living in the Calchaquà Valleys of the Argentinean Andes in the town of Cachi at 2300 m. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to moderate hypoxia at a intermediate altitude. DNA from 24 saliva samples of CalchaquÃes living at 2300 m in Cachi in the Province of Salta in Argentina was genotyped.
2014-04-05 | E-GEOD-56518 | biostudies-arrayexpress
Project description:This study evaluates genetic and phenotypic variation in the high altitude Colla population living in the Argentinean Andes above 3500 m. They were compared to the Wichí population living in the nearby lowlands of the Gran Chaco region. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to hypobaric hypoxia. We have genotyped 25 individuals from both populations for 730,525 SNPs.
2014-02-20 | GSE55175 | GEO
Project description:This study evaluates genetic and phenotypic variation in the high altitude Colla population living in the Argentinean Andes above 3500 m. They were compared to the Wichà population living in the nearby lowlands of the Gran Chaco region. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to hypobaric hypoxia. We have genotyped 25 individuals from both populations for 730,525 SNPs. DNA from 25 saliva samples from Collas living >3500 m and 25 saliva samples from Wichà living <500 m from the Province of Salta in Argentina was genotyped
2014-02-20 | E-GEOD-55175 | biostudies-arrayexpress
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression.
2011-02-19 | GSE20463 | GEO
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression. Two-condition experiment, Normoxic MSCs vs. Hypoxic MSCs.
2011-02-19 | E-GEOD-20463 | biostudies-arrayexpress
Project description:<p>Hypoxic training is a method by athletes to enhance their performance at sea level or improve their cardiovascular endurance in moderate-altitude competitions. Comparative studies involving populations from low and moderate altitudes offer an opportunity to understand the mechanisms behind adaptation to hypoxia. Data from GC-MS and LC-MS were combined to compare metabolic profiles of plasma between moderate- and low-altitude adolescent athletes. A total of 161 differential metabolites were identified, including 84 up-regulated and 77 down-regulated metabolites in moderate-altitude adolescents compared to their low-altitude counterparts. Pathway analysis revealed that the significantly different metabolites were associated with carbohydrate, amino acid and lipid metabolism. Lipid metabolism pathways such as linolenic and linoleic acid metabolism, sphingolipid metabolism and arachidonic acid metabolism, as well as processes involving the transfer of acetyl groups into mitochondria and fatty acid biosynthesis, were significantly altered in the moderate-altitude athletes. Receiver operating characteristic analysis detected glycerol and oxo-proline metabolites with a good range of sensitivity and specificity. These metabolites were chosen as biomarker of chronic adaptation to moderate altitude. This study demonstrates differences in metabolic profiles between moderate- and low-altitude populations and highlights the potential of these differential metabolites and metabolic pathways to provide new insights into the mechanisms of adaptation to moderate-altitude</p>
2025-02-27 | MTBLS10841 | MetaboLights
Project description: Not available
| S-EPMC2531291 | biostudies-literature
Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.
2019-07-31 | GSE114179 | GEO