Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA246309 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:RNA-Seq Identifies Novel Myocardial Gene Expression Signatures of Heart Failure [RNA-seq]
| PRJNA246308 | ENA
Project description:RNA-Seq Identifies Novel Myocardial Gene Expression Signatures of Heart Failure
| PRJNA246307 | ENA
Project description:Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, as these 40 patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with partial myocardial functional recovery induced by LVAD; however, the mechanisms underlying this favorable response are incompletely understood. To identify molecular signatures of recovery, we studied paired pre- and post-LVAD myocardial samples from heart failure patients who received LVAD as a bridge-to-transplant (10 responders, 9 non-responders) and non-failing controls. We performed bulk RNA-sequencing, tandem-mass-tag (TMT) quantitative proteomics, and TMT quantitative phospho-proteomics with follow-up mechanistic and functional 50 investigations in primary rodent cardiomyocytes and human engineered heart tissues (EHTs).
2026-01-12 | PXD068397 | Pride
Project description:Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, as these 40 patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with partial myocardial functional recovery induced by LVAD; however, the mechanisms underlying this favorable response are incompletely understood. To identify molecular signatures of recovery, we studied paired pre- and post-LVAD myocardial samples from heart failure patients who received LVAD as a bridge-to-transplant (10 responders, 9 non-responders) and non-failing controls. We performed bulk RNA-sequencing, tandem-mass-tag (TMT) quantitative proteomics, and TMT quantitative phospho-proteomics with follow-up mechanistic and functional 50 investigations in primary rodent cardiomyocytes and human engineered heart tissues (EHTs).
2026-01-12 | PXD068395 | Pride
Project description:Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, as these 40 patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with partial myocardial functional recovery induced by LVAD; however, the mechanisms underlying this favorable response are incompletely understood. To identify molecular signatures of recovery, we studied paired pre- and post-LVAD myocardial samples from heart failure patients who received LVAD as a bridge-to-transplant (10 responders, 9 non-responders) and non-failing controls. We performed bulk RNA-sequencing, tandem-mass-tag (TMT) quantitative proteomics, and TMT quantitative phospho-proteomics with follow-up mechanistic and functional 50 investigations in primary rodent cardiomyocytes and human engineered heart tissues (EHTs).
2026-01-12 | PXD068672 | Pride
Project description:Left ventricular myocardial transcriptomic profiling was performed in rats subjected to transverse aortic constriction (TAC)-induced heart failure and sham-operated controls to investigate gene expression changes associated with pressure overload-induced cardiac remodeling. The dataset was used in studies investigating novel molecular targets in heart failure, including G-protein-coupled receptor (GPCR)-associated pathways and microRNA-regulated target networks.
2026-06-11 | E-MTAB-17114 | biostudies-arrayexpress
Project description:We aim to study the gene alteration in diabetic failing heart and decipher the molecular mechanisms underlying diabetes-associated heart failure. Diabetic patients are more vulnerable to cardiac dysfunction. The pathogenesis of diabetes-associated heart failure is multiple, including cardiac pathological remodeling, intracellular metabolic disorders, cardiac inflammation, etc. To determine which signaling pathways causes the myocardial alterations, we plan to identify the individual gene function during the pathogenesis using an unbiased large-scale screening. Firstly, gene expression should be assessed. RNA-seq is used to detect gene changes, afterwards, the potential candidates involved in the molecular basis induing diabetic heart failure will be validated by other assessment and function study will be performed to explore their role in the onset and progression of heart failure in diabetes.
2026-02-20 | E-MTAB-16575 | biostudies-arrayexpress
Project description:We aim to study the gene alteration in diabetic failing heart and decipher the molecular mechanisms underlying diabetes-associated heart failure. Diabetic patients are more vulnerable to cardiac dysfunction. The pathogenesis of diabetes-associated heart failure is multiple, including cardiac pathological remodeling, intracellular metabolic disorders, cardiac inflammation, etc. To determine which signaling pathways causes the myocardial alterations, we plan to identify the individual gene function during the pathogenesis using an unbiased large-scale screening. Firstly, gene expression should be assessed. RNA-seq is used to detect gene changes, afterwards, the potential candidates involved in the molecular basis induing diabetic heart failure will be validated by other assessment and function study will be performed to explore their role in the onset and progression of heart failure in diabetes. Samples are healthy subject versus those with diabetes with cardiovascular disease (CVD) and heart failure (HF)
2026-08-14 | E-MTAB-16712 | biostudies-arrayexpress