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Gallus gallus

ABSTRACT: MicroRNA expression in chicken cecum following Campylobacter jejuni infection

PROVIDER: PRJNA253402 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1449902.fastq.gz	Fastqsanger.gz
	SRR1449903.fastq.gz	Fastqsanger.gz
	SRR1449904.fastq.gz	Fastqsanger.gz
	SRR1449905.fastq.gz	Fastqsanger.gz

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Project description:MicroRNA expression in chicken cecum following Salmonella Enteritidis infection

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Project description:Campylobacter jejuni is a common cause of diarrheal disease worldwide. Human infection typically occurs through the ingestion of contaminated poultry products. We previously demonstrated that an attenuated Escherichia coli live vaccine strain expressing the C. jejuni N-glycan on its surface reduces the Campylobacter load in more than 50% of vaccinated leghorn and broiler birds to undetectable levels (responder birds), whereas the remainder of the animals were still colonized (non-responders). To understand the underlying mechanism, we conducted 3 larger scale vaccination and challenge studies using 135 broiler birds and found a similar responder/non responder effect. The submitted data were used for a genome-wide association study of the chicken responses to glycoconjugate vaccination against Campylobacter jejuni.

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Project description:Campylobacter jejuni is a human pathogen which causes campylobacteriosis, one of the most widespread zoonotic enteric diseases worldwide. Most cases of sporadic C. jejuni infection occur through the handling or consumption of undercooked chicken meat, or cross-contamination of other foods with raw poultry fluid. A common practice to combat Campylobacter infection is to treat chickens with chlorine which kills the microbe. This analysis aimed to elucidate the transcriptomic response of Campylobacter jejuni treated with hypochlorite through Illumina sequencing. C. jejuni was grown and treated with hypochlorite. Samples were taken 5, 20 and 45 min after treatment for RNAseq analysis.The data generated were compared to the transcriptome pre-exposure to determine C. jejuni's response to hypochlorite.

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Project description:Genome-Wide Gene Expression Profiling Of Chicken Spleen Responding To Campylobacter jejuni Infection In Broilers

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