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Homo sapiens

ABSTRACT: RepliSeq of HT-1080 cell line

PROVIDER: PRJNA253850 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR1482430_1.fastq.gz	Fastqsanger.gz
	SRR1482430_2.fastq.gz	Fastqsanger.gz
	SRR1482431_1.fastq.gz	Fastqsanger.gz
	SRR1482431_2.fastq.gz	Fastqsanger.gz
	SRR1482426_1.fastq.gz	Fastqsanger.gz

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RepliSeq of HT-1080 cell line

2014-07-31 | GSE58907 | GEO

Development of gene expression signatures for subconfluent and overconfluent HT-1080 fibrosarcoma cell line

Project description:We investigated the changes in gene expression profile between subconfluent (80%) and overconfluent HT-1080 fibrosarcoma cell line. We have employed whole genome microarray expression profiling as a discovery platform to identify genes expression profiles in HT-1080 cells. Total RNAs from subconfluent (HT-1080_80%) and overconfluent (HT-1080_overconfluent) HT-1080 cells were harvested and subjected to the microarray analysis.

2015-06-04 | E-GEOD-69534 | biostudies-arrayexpress

RepliSeq of HT-1080 cell line

Project description:Analysis of replication timing by RepliSeq of HT-1080 Human Connective Tissue Fibrosarcoma Cells. HT-1080 subclone +4 cell line as described in “Human gene targeting favors insertions over deletions.” Russell, D.W., and Hirata, R.K. (2008). Hum Gene Ther 19, 907-914. RepliSeq of HT-1080 cell line was used to determine the impact of DNA replication on targeted adeno-associated virus sites by mapping replication forks, which revealed a consistent preference for recombination at target loci transcribed towards an incoming fork.

2014-07-31 | E-GEOD-58907 | biostudies-arrayexpress

Homo sapiens

Project description:Development of gene expression signatures for subconfluent and overconfluent HT-1080 fibrosarcoma cell line

| PRJNA285803 | ENA

Development of gene expression signatures for subconfluent and overconfluent HT-1080 fibrosarcoma cell line

Project description:We investigated the changes in gene expression profile between subconfluent (80%) and overconfluent HT-1080 fibrosarcoma cell line.

2015-06-04 | GSE69534 | GEO

Proteomic analysis of HT-1080 cells overexpressing protein ARGLU1

Project description:A proteomic comparison between normal HT-1080 cells and HT-1080 cells that have been stably transfected to overexpress protein arginie and glutamate rich 1 (ARGLU1).

2024-05-13 | PXD046329 | Pride

Homo sapiens

Project description:Expression Data for HT-1080 cells exposed to ETP, QUE and MMS

| PRJNA255203 | ENA

total RNA-seq from HT1080 (ENCSR535VTR)

Project description:The libraries contained in this experiment come from independent growths of cell line HT-1080, a connective tissue fibrosarcoma from a 35 year old male. They are stranded PE101 Illumina Hi-Seq libraries from rRNA-depleted Total RNA > 200 nucleotides in size. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2016-03-18 | GSE78653 | GEO

RAMPAGE from HT1080 (ENCSR348DYP)

Project description:The libraries contained in this experiment come from independent growths of cell line HT-1080, a connective tissue fibrosarcoma from a 35 year old male. They are stranded PE101 Illumina Hi-Seq RAMPAGE libraries from rRNA-depleted Total RNA > 200 nucleotides in size. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2016-11-08 | GSE88210 | GEO

KIF20A promotes the development of soft tissue sarcoma by activating the PI3K-AKT signaling pathway

Project description:Soft tissue sarcoma (STS) is a group of malignancies that can appear in any part of the body. The prognosis of STS patients remains unsatisfactory, mainly due to metastasis and recurrence. Upregulation of KIF20A is associated with poor prognosis of STS patients, but its downstream mechanism is unknown. In the present study, we found that downregulation of KIF20A in the STS cell line HT-1080 inhibits cell proliferation, migration, and invasion and induced cell apoptosis and G2/M arrest in vitro. In addition, downregulation of KIF20A in HT-1080 repressed tumorigenesis of STS in a xenograft mouse model. Pathway analysis showed, that downregulation of KIF20A led to suppression of downstream PI3K-AKT and NF-κB pathways. Specifically, the phosphorylation of AKT at Ser473 was inhibited. Taken together, our results indicate that KIF20A plays an important role in the development of STS by inhibiting cell proliferation, migration, invasion via the PI3K-AKT signaling pathway. Therefore, KIF20A is a potential therapeutic target in STS.

2020-11-23 | GSE140074 | GEO

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