Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

ABSTRACT: Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

PROVIDER: PRJNA258256 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1552240.fastq.gz	Fastqsanger.gz
	SRR1552250.fastq.gz	Fastqsanger.gz
	SRR1552260.fastq.gz	Fastqsanger.gz
	SRR1552270.fastq.gz	Fastqsanger.gz
	SRR1552280.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 70

Similar Datasets

Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

Project description:We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species (GSE60428) and HiC analysis in Drosophila melanogaster. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter HiC experiments in wild type drosophila embryos

2014-10-20 | E-GEOD-61471 | biostudies-arrayexpress

Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

Project description:We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter ChIP-seq analysis of histone marks and chromatin associated factors across 4-5 Drosophila species

2014-10-20 | E-GEOD-60428 | biostudies-arrayexpress

Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

Project description:We report the evolutionary behaviour of Polycomb group proteins, their recruitment factors and their underlying sequences by performing ChIP-seq analysis in 4-5 different Drosophila species. We demonstrate an extremely high conservation of Polycomb repressive domains across Drosophila species We validate few cases of PRE divergence that shows that cis-driven PRE evolution is a rare event. We further show that PHO recruitment to Polycomb domains is evolutionarily robust to motif changes and that PRC1 stabilizes binding of its key recruiter

2014-10-20 | GSE60428 | GEO

Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

2014-10-20 | GSE61471 | GEO

Drosophila melanogaster

Project description:Cooperativity, specificity and evolutionary stability of Polycomb targeting in Drosophila

| PRJNA261249 | ENA

Homotypic cooperativity and collective binding are determinants of bHLH specificity and function

Project description:Homotypic cooperativity and collective binding are determinants of bHLH specificity and function

| PRJNA555089 | ENA

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

Project description:The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C terminus, which can be exploited by fusion to transcriptional regulators beyond SS18. Accordingly, SS18-SSX recruitment occurs in a manner that is independent of the core components and catalytic activity of BAF. Alternative SSX fusions are also recruited to H2AK119ub1-rich chromatin and reproduce the expression signatures of SS18-SSX by engaging with transcriptional activators. Variant Polycomb repressive complex 1.1 (PRC1.1) acts as the main depositor of H2AK119ub1 and is therefore required for SS18-SSX occupancy. Importantly, the SSX C terminus not only depends on H2AK119ub1 for localization, but also further increases it by promoting PRC1.1 complex stability. Consequently, high H2AK119ub1 levels are a feature of murine and human synovial sarcomas. These results uncover a critical role for SSX-C in mediating gene deregulation in synovial sarcoma by providing specificity to chromatin and further enabling oncofusion binding by enhancing PRC1.1 stability and H2AK119ub1 deposition.

2023-05-24 | GSE233376 | GEO

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

2023-05-24 | GSE233375 | GEO

Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli

Project description:Terminal differentiation strategy for evolutionary stability

| PRJEB56582 | ENA

Cooperative assembly confers regulatory specificity and long-term genetic circuit stability

Project description:Cooperative assembly confers regulatory specificity and long-term genetic circuit stability

| PRJNA838831 | ENA