Mustela putorius furo
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA259289 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:A restricted period for formation of Outer Subventricular Zone defined by Cdh1 and Trnp1 levels
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Project description:The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunological insights are restricted due to a lack of ferret-specific reagents and limited genetic information about ferret B and T cell receptors. Here, variable, diversity and joining genes within the ferret kappa, lambda and heavy chain immunoglobulin loci were annotated using available genomic information. A multiplex PCR approach was derived that facilitated the recovery of paired heavy and light chain immunoglobulin sequences from single sorted ferret B cells, allowing validation of predicted germline gene sequences and the identification of putative novel germlines. Eukaryotic expression vectors were developed that enabled the generation of recombinant ferret monoclonal antibodies. This work advances the ferret as an informative immunological model for viral diseases by allowing the in-depth interrogation of antibody-based immunity.
| S-EPMC7259655 | biostudies-literature
Project description:We investigated sleep ontogenesis in the ferret-a placental mammal that is highly altricial compared to other mammalian species. Because altriciality is linked with elevated rapid-eye-movement (REM) sleep amounts during infancy, it was expected that ferret kits would display very high levels of this state. Longitudinal polysomnographic measurements were made from 8 ferret kits from approximately eye-opening (postnatal day [P]30)-P50 using an experimental routine that minimized the effects of maternal separation. These data were compared to values from 8 adult ferrets (>3 months of age) and 6 neonatal cats (mean age: P31.7). We find that the polygraphic features of REM and non-REM (NREM) sleep are present by at least P30. Over the next 2 weeks, REM sleep amounts slightly declined while wakefulness and NREM sleep amounts increased. However, a comparison to published values from developing cats and rats showed that the ferret did not exhibit a disproportionate amount of REM sleep at similar postnatal ages or relative to a common developmental milestone (eye-opening).
| S-EPMC2527623 | biostudies-literature
Project description:Gene expression profiles in lymph nodes from ferrets infected with A/California/07/2009
| PRJNA151609 | ENA
Project description:Peripheral blood mononuclear cells as a source of cold exposure biomarkers
| PRJNA263901 | ENA
Project description:Differential kinetics of host responses during infection with genetically distinct henipavirus strains in a lethal ferret model
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Project description:Gene expression analysis of inguinal white adipose tissue upon cold exposure in ferrets: mainly metabolism is effected
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Project description:IF002 - Custom designed Agilent arrays result on the Cystic Fibrosis model in ferrets.
| PRJNA212789 | ENA
Project description:IF001 - Microarray analysis from ferret infections with highly pathogenic reconstructed H1N1 1918 influenza virus.
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Project description:Early CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
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