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Clostridioides difficile strain:SA10-050

ABSTRACT: Peptoclostridium difficile virulent strain that contains a modified version of the Pathogenicity Locus

PROVIDER: PRJNA260039 | ENA |

REPOSITORIES: ENA

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			Action	DRS
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	SRR1564710.fastq.gz	Fastqsanger.gz

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An intact S-layer is advantageous to Clostridioides difficile within the host.

Project description:The S-layer of C. difficile is a paracrystalline array that covers the bacterial cell but its contribution to overall disease remains unclear. A previously described spontaneous slpA-null mutant, FM2.5, with a point mutation in slpA offers the opportunity to study the role of the S-layer in vivo. Here, we confirm our previous observation that this strain is less virulent in vivo despite effectively colonising the host and producing toxin. We also show a strong in vivo selection pressure for strains that express the intact S-layer array through sequence modifications that restore slpA expression. While such modifications do not affect the overall S-layer structure, RNA-Seq analysis in vitro showed large differences in gene expression between FM2.5, the revertant strains and R20291. Despite these differences, an intact S-layer clearly provides a selective advantage of C. difficile in the host, and, for one of the revertants tested, helped restore disease severity.

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