Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bos taurus

ABSTRACT: Transcriptomic response of bovine dermal fibroblasts to lipopolysaccharide

PROVIDER: PRJNA260094 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1568130.fastq.gz	Fastqsanger.gz
	SRR1568140.fastq.gz	Fastqsanger.gz
	SRR1568131.fastq.gz	Fastqsanger.gz
	SRR1568141.fastq.gz	Fastqsanger.gz
	SRR1568132.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Bos taurus

Project description:Breed-dependent differences in transcriptomic response of dermal fibroblasts to lipopolysaccharide

| PRJNA292867 | ENA

Bos taurus

Project description:Influence of bovine virus diarrhoea virus on the transcriptome profile of bovine endometrium in response to bacterial lipopolysaccharide.

| PRJNA291875 | ENA

Bos taurus

Project description:MIRA-Seq analysis of bovine dermal fibroblasts from the same individuals at two different ages

| PRJNA260222 | ENA

Bos taurus

Project description:MIRA-Seq analysis of bovine dermal fibroblasts isolated from two breeds of cattle, Holstein (dairy breed) and Angus (beef breed).

| PRJNA292866 | ENA

Bos taurus

Project description:Bovine granulosa cell response to FGF18

| PRJNA177124 | ENA

Global mapping of miRNA-target interactions in cattle (Bos taurus)

Project description:With regulatory roles in development, cell proliferation and disease, micro-RNA (miRNA) biology is of great importance and a potential key to novel RNA-based therapeutic regimens. Biochemically based sequencing approaches have provided robust means of uncovering miRNA binding landscapes on transcriptomes of various species. However, a current limitation to the therapeutic potential of miRNA biology in cattle is the lack of validated miRNAs targets. Here, we use cross-linking immunoprecipitation (CLIP) of the Argonaute (AGO) proteins and unambiguous miRNA-target identification through RNA chimeras to define a regulatory map of miRNA interactions in the cow (Bos taurus). The resulting interactome is the deepest reported to date for any species, demonstrating that comprehensive maps can be empirically obtained. We observe that bovine miRNA targeting principles are consistent with those observed in other mammals. Motif and structural analyses define expanded pairing rules with most interactions combining seed-based pairing with distinct, miRNA-specific patterns of auxiliary pairing. Further, miRNA-target chimeras had predictive value in evaluating true regulatory sites of the miR-17 family. Finally, we define miRNA-specific targeting for >5000 mRNAs and determine gene ontologies (GO) for these targets. This confirmed repression of genes important for embryonic development and cell cycle progress by the let-7 family, and repression of those involved in cell cycle arrest by the miR-17 family, but it also suggested a number of unappreciated miRNA functions. Our results provide a significant resource for transcriptomic understanding of bovine miRNA regulation, and demonstrate the power of experimental methods for establishing comprehensive interaction maps.

2017-07-11 | GSE90089 | GEO

Bos taurus

Project description:Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology

| PRJNA160133 | ENA

Transcriptional profiling of cumulus cells entoured the oocyte after in vitro or in vivo maturation in bovine (Bos taurus)

Project description:In vitro maturation (IVM) of the oocytes is a routine method in bovine embryo production. The competence of bovine oocytes to develop into embryo after IVM and in vitro fertilization (IVF) is lower as compared to in vivo preovulatory oocytes. Cumulus cells (CC) that enclose an oocyte are involved in the acquisition of oocyte quality during maturation. Using transcriptomic approach we compared cumulus cells gene expression during IVM with that in vivo preovulatory period.

2011-08-09 | GSE31261 | GEO

Bos taurus

Project description:Transcriptome analysis of FSH response in bovine cumulus cells

| PRJNA281390 | ENA

Bos taurus

Project description:Transcriptomic analysis of bovine macrophages exposed to Rhipicephalus microplus saliva

| PRJDB35830 | ENA