Project description:AZD4547,pan-FGFR inhibitor, have been reported to have profound therapeutic effects on FGFR-deregulated cancers. AN3-CA is one of endometrial cancer cell lines harbouring FGFR2 mutants. AZD4547 showed a potent antiprolierative effect on AN3-CA cells. we used microarray to investigate transcriptome-wide change in gene expression followinig 300 nM AZD4547 treatment to explain the chemotherapeutic effect.
Project description:AZD4547,pan-FGFR inhibitor, have been reported to have profound therapeutic effects on FGFR-deregulated cancers. AN3-CA is one of endometrial cancer cell lines harbouring FGFR2 mutants. AZD4547 showed a potent antiprolierative effect on AN3-CA cells. we used microarray to investigate transcriptome-wide change in gene expression followinig 300 nM AZD4547 treatment to explain the chemotherapeutic effect. compound treatment with or without ligand stimulus.
Project description:Study #1: U266 cells were treated with 100 nM PF477736 for 4 hr. Study #2: U266 cells were treated with 100 nM PF477736 for 16 hr. Study #3: KAS/6-1 cells were treated with 50 nM PF477736 or 300 nM CEP3891 for 2 hr.
Project description:Gene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
