Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fervidobacterium islandicum strain:AW-1

ABSTRACT: Fervidobacterium islandicum strain:AW-1 Genome sequencing

PROVIDER: PRJNA263006 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Multiomics analysis of keratin degradation by Fervidobacterium islandicum AW-1

Project description:Firmicutes and dermatophytes degrade recalcitrant insoluble keratins resistant to proteolysis. Such highly ordered peptide fibrils can be digested through proteolysis as well as sulfitolysis. However, its biological mechanism relevant to keratin degradation remains unclear. Here we present genome-wide multi-omics analyses to describe how the extremophilic bacterium Fervidobacterium islandicum AW-1degrades keratin under stress conditions. Physiological and biochemical evidence integrated with multi-omics data reveals a nutrient deprivation-induced metabolic shift, thereby increasing chemotactic persister formation for cellular adhesion to keratins and activating the membrane-associated keratinolysis. Quantitative dynamic gene expression and metabolite profiling confirmed that stringent response-induced flagella synthesis is a prerequisite for biofilm formation and that keratin degradation is responsible for swarming dispersal. This study illustrates the molecular details of keratinolysis, providing insight into the survivability of primordial bacteria coping with scarce nutrition relevant to recurrent infections with superficial pathogens.

2026-03-16 | PXD027063 | Pride

Fervidobacterium islandicum

Project description:Fervidobacterium islandicum overview

| PRJNA344811 | ENA

Fervidobacterium islandicum strain:H-21

Project description:Fervidobacterium islandicum strain:H-21 Genome sequencing

| PRJNA814012 | ENA

Proteomic analysis of Fervidobacterium islandicum H-21 cultivated on feather or glucose

Project description:With the aim to understand the key enzymes involved in the degradation of feather by the thermophilic bacterium Fervidobacterium islandicum H-21, a deep shotgun proteomic analysis was performed on cells cultivated on feather or glucose, as well as on their exoproteome.

2025-05-07 | PXD054272 | Pride