Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA264058 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR1613961.fastq.gz | Fastqsanger.gz | |||
| SRR1613962.fastq.gz | Fastqsanger.gz | |||
| SRR1613963.fastq.gz | Fastqsanger.gz | |||
| SRR1613964.fastq.gz | Fastqsanger.gz | |||
| SRR1613965.fastq.gz | Fastqsanger.gz |
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Project description:Small cell lung cancer (SCLC) is an aggressive disease with high mortality. The identification of effective pharmacological strategies to target SCLC biology represents an urgent need. Using a high-throughput cellular screen of a diverse chemical library we observe that SCLC is sensitive to transcription-targeting drugs, and in particular to THZ1, a newly identified covalent inhibitor of cyclin-dependent kinase 7 (CDK7). We find that expression of super-enhancer associated transcription factor genes including MYC family proto-oncogenes and neuroendocrine lineage-specific factors are highly vulnerability to THZ1 treatment. We propose that downregulation of these transcription factors contributes, in part, to SCLC sensitivity to transcriptional inhibitors and that THZ1 represents a novel treatment paradigm for targeted SCLC therapy. Microarray expression in small cell lung cancer lines treated with DMSO or THZ1
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