Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

ABSTRACT: BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

PROVIDER: PRJNA267658 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells

Project description:Triple negative breast cancer (TNBC) has poor prognostic outcome compared to other types of breast cancer1. At present the molecular and cellular mechanisms underlying TNBC pathology are not well understood1. Here we report that the transcription factor BCL11A is overexpressed in TNBC including basal-like breast cancer (BLBC) and that its genomic locus is amplified in up to 38% of BLBC tumours. BCL11A overexpression in immortalised human breast epithelial cells promotes tumour formation in xenograft models, whereas knockdown of BCL11A in TNBC cell lines suppresses their tumourigenic potential. In the DMBA-induced mouse mammary tumour model, Bcl11a is found to be essential for tumourigenesis since deletion of Bcl11a before DMBA treatment substantially decreases tumour formation, even in p53-null cells, and inactivation of Bcl11a in established tumours causes their regression. At the cellular level, BCL11A overexpression enhances clonogenicity in vitro whereas its deletion in the mouse causes a reduction in the number of mammary epithelial stem and progenitor cells. Thus, BCL11A has an important role in the genesis of TNBC and in normal mammary epithelial cells. This study highlights the importance of further investigation of BCL11A in breast cancer diagnosis and targeted therapies.

2014-11-18 | GSE63386 | GEO

BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.

Project description:Triple-negative breast cancer (TNBC) has poor prognostic outcome compared with other types of breast cancer. The molecular and cellular mechanisms underlying TNBC pathology are not fully understood. Here, we report that the transcription factor BCL11A is overexpressed in TNBC including basal-like breast cancer (BLBC) and that its genomic locus is amplified in up to 38% of BLBC tumours. Exogenous BCL11A overexpression promotes tumour formation, whereas its knockdown in TNBC cell lines suppresses their tumourigenic potential in xenograft models. In the DMBA-induced tumour model, Bcl11a deletion substantially decreases tumour formation, even in p53-null cells and inactivation of Bcl11a in established tumours causes their regression. At the cellular level, Bcl11a deletion causes a reduction in the number of mammary epithelial stem and progenitor cells. Thus, BCL11A has an important role in TNBC and normal mammary epithelial cells. This study highlights the importance of further investigation of BCL11A in TNBC-targeted therapies.

| S-EPMC4338552 | biostudies-literature

BCL11A: A Novel Breast Cancer Gene which Plays a Critical Role in Mammary Stem Cells and Progenitors

2014-11-18 | E-GEOD-63386 | biostudies-arrayexpress

Interaction of BCL11A and CHD8 in triple negative breast cancer

Project description:Interaction of BCL11A and CHD8 in triple negative breast cancer

| PRJNA728695 | ENA

Interaction of BCL11A and CHD8 in triple negative breast cancer [RNA-seq]

Project description:BCL11A interacts with and recruits the chromatin remodeller, CHD8 and this interaction is essential for mediating the oncogenic activity of BCL11A.

2025-05-08 | GSE174186 | GEO

Interaction of BCL11A and CHD8 in triple negative breast cancer [ChIP-seq]

Project description:BCL11A interacts with and recruits the chromatin remodeller, CHD8 and this interaction is essential for mediating the oncogenic activity of BCL11A.

2025-05-08 | GSE174184 | GEO

Interaction of BCL11A and CHD8 in triple negative breast cancer [ATAC-seq]

Project description:BCL11A interacts with and recruits the chromatin remodeller, CHD8 and this interaction is essential for mediating the oncogenic activity of BCL11A.

2025-05-08 | GSE174181 | GEO

Interaction of BCL11A and CHD8 in triple negative breast cancer [ATAC-seq]

Project description:Interaction of BCL11A and CHD8 in triple negative breast cancer [ATAC-seq]

| PRJNA728688 | ENA

Interaction of BCL11A and CHD8 in triple negative breast cancer [RNA-seq]

Project description:Interaction of BCL11A and CHD8 in triple negative breast cancer [RNA-seq]

| PRJNA728699 | ENA

Interaction of BCL11A and CHD8 in triple negative breast cancer [ChIP-seq]

Project description:Interaction of BCL11A and CHD8 in triple negative breast cancer [ChIP-seq]

| PRJNA728698 | ENA