Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Molecular phenotyping of a test compound (small-molecule neurotransmitter receptor antagonist) in primary human hepatocytes

PROVIDER: PRJNA271358 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1736850.fastq.gz	Fastqsanger.gz
	SRR1736860.fastq.gz	Fastqsanger.gz
	SRR1736870.fastq.gz	Fastqsanger.gz
	SRR1736880.fastq.gz	Fastqsanger.gz
	SRR1736851.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 41

Similar Datasets

Molecular phenotyping of a test compound (small-molecule neurotransmitter receptor antagonist) in primary human hepatocytes

Project description:Expression profiles of 917 pathway repoter genes were determined by AmpliSeq-RNA in primary human hepatocytes treated with Diclofenac and a test compound 3 hours after treatment. Vehicle control, diclofenac, and three doses of the test compound (small-molecule neurotransmitter receptor antagonist) were applied to three primary cell lines, with three biological replicates in each group. In some treatment groups read-outs were only available for two samples. All together 41 samples were profiled.

2015-07-01 | E-GEOD-64588 | biostudies-arrayexpress

Molecular phenotyping of a test compound (small-molecule neurotransmitter receptor antagonist) in primary human hepatocytes

2015-07-01 | GSE64588 | GEO

E-GEOD-21031

Project description:Time-series of IL-6 stimulated primary mouse hepatocytes

2015-09-15 | E-GEOD-21031 | ExpressionAtlas

E-MTAB-4444

Project description:Transcription profiling of primary mouse hepatocytes under different culture conditions

2016-02-08 | E-MTAB-4444 | ExpressionAtlas

E-GEOD-11941

Project description:Transcription profiling by array of human primary hepatocytes treated with trovafloxacin

2025-01-16 | E-GEOD-11941 | ExpressionAtlas

Transcription profiling of mouse skin treated with ovalbumin to induce atopic dermatitus and then treated with a test drug or ramatroban or dexamethasone

Project description:A highly specific and potent small molecule antagonist of CRTH2 (chemoattractant receptor) was used to investigate the role of this Prostaglandin D2 (PGD2) receptor in chronic models of cutaneous inflammation and the underlying immune response. These RNA samples are from mice that were in a chronic (50 day) model of atopic dermatitis. Each mouse had a section of back skin patched with a gauze, and the RNA was from the patched area of skin; the control mice had the gauze soaked in PBS, whereas all the other test mice had the gauze soaked in ovalbumin dissolved in PBS. The ovalbumin acts as an allergen and induces the experimental atopic dermatitis. The six groups of mice that received the OVA patch were treated in different ways:some received just the drug vehicle during the OVA patching, others received the test drug (compound A) at 3 different concentrations: 10 mg/kg 1 mg/kg and 0.1 mg/kg. Two other cohorts received positive control drugs: ramatroban and dexamethasone .Each different sample represents a different animal.

2009-06-25 | E-TABM-505 | biostudies-arrayexpress

E-GEOD-17251

Project description:Transcription profiling by array of human primary hepatocytes after treatment with pirinixic acid

2025-01-24 | E-GEOD-17251 | ExpressionAtlas

E-GEOD-31455

Project description:Primary human hepatocytes treated with IL28B and the HCV JFH1 Genotype 2A clone.

2025-01-24 | E-GEOD-31455 | ExpressionAtlas

Transcription profiling of mouse mast cells treated with an antagonist for recepter CRTH2, compound A alone and with CRTH2 ligands, antigen, BW868c and dexatheasone

Project description:These samples are part of a study in which we demonstrate that mast cells express the receptor CRTH2, which is the target for our antagonist compound compound A. We want to examine whether there are differences in RNA expression when the mast cells are treated with the ligands of CRTH2 - PGD2 and DK-PGD2 - compared to no treatment. Also, we want to see if pretreating the cells with compound A can block or change differences in RNA expression induced by either DK-PGD2 or PGD2. The study also looks at Ige loaded cells exposed to antigen and dexamethasone, and cells treated with BW868c - a a highly selective DP receptor antagonist.

2010-06-25 | E-TABM-498 | biostudies-arrayexpress

Single-cell transcriptomics reveals heterogeneous metabolic profiles in primary human hepatocytes

Project description:Through scRNA-sequencing of primary human hepatocytes (PHHs), we have identified four subgroups of hepatocytes. A phenotyping 5-probe cocktail (Sanofi-Aventis) has been used to assess their metabolic capacity. Upon cocktail treatment, the characterized four hepatocyte subgroups displayed differential gene expression profiles and exhibited xenobiotic metabolism-related specialization. Intracellular lipid accumulation achieved through loading the cells with free fatty acids (FFA, 2:1 oleic:palmitic acid), differently affected the four subgroups. Moreover, we have shown that intracellular fat accumulation diminishes the drug-related metabolic capacity of hepatocytes.

2023-09-19 | E-MTAB-11530 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data