Ovis aries
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA274132 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR1781950.fastq.gz | Fastqsanger.gz | |||
| SRR1781960.fastq.gz | Fastqsanger.gz | |||
| SRR1781951.fastq.gz | Fastqsanger.gz | |||
| SRR1781961.fastq.gz | Fastqsanger.gz | |||
| SRR1781952.fastq.gz | Fastqsanger.gz |
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Project description:Transcriptome profiling of the ovine pars tuberalis in long and short photoperiod conditions [4-22 weeks]
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Project description:Expression profiling of prion accumulating ovine microglia
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Project description:Three groups of adult ewes were initally submitted to short days. One group remained in short days (Short), the other two were transferred to long days - one was intact (Long), the other had been subject to thyroidectomy before the photoperiodic transfer (THX). At the end of the treatment (see Lomet et al 2018 CelMolLifeSci 75:905-918) ewes were killed and extracts from the choroid plexus (from lateral ventricles) were taken and analyzed. Abstract: The photoperiodic control of seasonal functions requires the action of melatonin at the pars tuberalis of the pituitary and subsequent control of local thyroid hormone (TH) signaling by tanycytes lining the basolateral part of the third ventricle. Therefore, TH supply of tancytes through the cerebrospinal fluid (CSF) is central to photoperiodism and the choroid plexuses (CP), which produce the CSF, play a pivotal role. Here, the transcriptome of the CP of the lateral ventricles was established by RNAseq in ewes maintained under three experimental conditions: ewes exposed to a short photoperiod (SP), intact ewes submitted to an acute 3-week exposure to a long photoperiod (LP-Sham) and ewes thyroidectomized prior to the LP exposure (LP-THX). Statistical analysis of the data revealed 1169 genes impacted by photoperiod (SP vs LP comparison) and 575 genes sensitive to the TH status (LP vs LP-THX comparison). Even though twice as numerous as the genes impacted by TH, genes responsive to photoperiod comparatively displayed rather weak transcriptional changes associated with a lower statistical significance. In line with this, validation of a few candidate DEG by RT-qPCR confirmed the impact of the TH status, but not that of photoperiod. We further showed that the expression level of the melatonin MT1 receptor is at best very low in the ewe CP, which provides a functional rationale for the lack of impact of photoperiod. In conclusion, while the CP is responsive to TH, which it provides to distant target tissues through the CSF, it is unlikely to be a major target of melatonin.
2025-06-24 | GSE250339 | GEO
Project description:Accurate timing and anticipation of seasonal changes are required to initiate physiological adaptations over the course of the year such as hibernation, changes in metabolism, fattening and reproductive activity. To achieve this, organisms have evolved complex seasonal timekeeping systems that rely on day length sensing (photoperiodism). The aim of this project is to investigate the role of the circadian clock in photoperiodism within the crucial photoperiod sensing tissue the pars tuberalis.
2020-02-04 | GSE144677 | GEO
Project description:Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries
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Project description:Genome-wide expression analysis of the mouse pars tuberalis (PT) under chronic short-day and long-day conditions
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Project description:Persistent free-running circannual (circa 1-year) rhythms have evolved in animals to regulate hormone cycles and time annual reproduction. In mammals, these are synchronized by environmental photoperiod and the melatonin signal. Long summer-like photoperiods (LP) activates thyrotrophs and thyroid-stimulating hormone (TSH) expression in the melatonin target tissue, the pars tuberalis (PT) region of the pituitary gland, driven by the transcriptional co-activator EYA3. TSH in turn stimulates thyroid hormone (TH) conversion in hypothalamic ependymal tanycytes, thus timing breeding seasons. In contrast to our new knowledge defining photoperiodic input, it is still not known which cells, tissues and pathways generate the underlying circannual cycle. We used seasonal sheep to characterise the circannual cycle, transferring animals from short winter-like photoperiods (SP) to prolonged LP conditions, and assaying prolactin to track circannual phase in individual animals. Using RNA-seq, we profiled PT cells at different phases of the circannual cycle, and defined extensive changes of cellular-remodeling pathways and genes encoding synaptic guidance proteins in the PT.
2015-10-09 | GSE65900 | GEO
Project description:Persistent free-running circannual (circa 1-year) rhythms have evolved in animals to regulate hormone cycles and time annual reproduction. In mammals, these are synchronized by environmental photoperiod and the melatonin signal. Long summer-like photoperiods (LP) activates thyrotrophs and thyroid-stimulating hormone (TSH) expression in the melatonin target tissue, the pars tuberalis (PT) region of the pituitary gland, driven by the transcriptional co-activator EYA3. TSH in turn stimulates thyroid hormone (TH) conversion in hypothalamic ependymal tanycytes, thus timing breeding seasons. In contrast to our new knowledge defining photoperiodic input, it is still not known which cells, tissues and pathways generate the underlying circannual cycle. We used seasonal sheep to characterise the circannual cycle, transferring animals from short winter-like photoperiods (SP) to prolonged LP conditions, and assaying prolactin to track circannual phase in individual animals. Using RNA-seq, we profiled PT cells at different phases of the circannual cycle, and defined extensive changes of cellular-remodeling pathways and genes encoding synaptic guidance proteins in the PT.
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Project description:Next Generation Sequencing of different ovine muscle's Transcriptomes
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