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FBXL10 Protects Polycomb-bound Genes from Hypermethylation

ABSTRACT: FBXL10 Protects Polycomb-bound Genes from Hypermethylation

PROVIDER: PRJNA274412 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1785990.fastq.gz	Fastqsanger.gz
	SRR1785991.fastq.gz	Fastqsanger.gz
	SRR1785992.fastq.gz	Fastqsanger.gz
	SRR1785993.fastq.gz	Fastqsanger.gz
	SRR1785987.fastq.gz	Fastqsanger.gz

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FBXL10 and the Protection of Polycomb-bound Genes from Hypermethylation (RRBS)

Project description:Nearly all CpG-dense promoters are occupied by the multi-domain chromosomal protein FBXL10. We show here that complete inactivation of the Fbxl10 gene leads to dense de novo methylation only of the promoters that are co-occupied by both FBXL10 and by Polycomb Repressive Complexes; this results in pervasive defects in embryonic development and death of homozygous Fbxl10 mutant embryos at midgestation. Deletion of key components of Polycomb Repressive Complexes 1 and 2 did not lead to ectopic de novo methylation. These results indicate that FBXL10 defends Polycomb-occupied promoters against ectopic de novo methylation. FBXL10 is the first reported factor whose loss leads to a gain in genomic DNA methylation.

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FBXL10 and the Protection of Polycomb-bound Genes from Hypermethylation (RRBS)

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FBXL10 Protects Polycomb-bound Genes from Hypermethylation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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FBXL10 Protects Polycomb-bound Genes from Hypermethylation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Fbxl10 regulates PRC1 recruitment to CpG islands and H2A ubiquitination

Project description:Polycomb repressive complex 1 (PRC1) catalyzes H2A monoubiquitination (uH2A) and regulates pluripotency in embryonic stem cells (ESCs). However the mechanisms controlling PRC1 recruitment and activity are largely unknown. Here we show that Fbxl10 interacts with Ring1B and Nspc1, forming a non-canonical PRC1. We demonstrate that Fbxl10-PRC1 is essential for H2A ubiquitination in mouse ESCs. Genome-wide analyses reveal that Fbxl10 preferentially binds to CpG islands and co-localizes with Ring1B on Polycomb target genes. Notably, Fbxl10 depletion causes modest dissociation of Ring1B but a major loss of uH2A on target genes. Furthermore rescue experiments for Fbxl10 reveal that its DNA binding capability and integration into PRC1 are required for proper H2A ubiquitination. ES cells lacking Fbxl10, like previously characterized Polycomb mutants, show a severely compromised capacity for successful differentiation. Our results shed light on a novel mechanism how CpG islands regulate chromatin function by affecting polycomb recruitment and activity.

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