Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Murine leukemia virus

ABSTRACT: RNA-Seq of RNAs encapsidated by Murine Leukemia Virus

PROVIDER: PRJNA275172 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1805258.fastq.gz	Fastqsanger.gz
	SRR1805259.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Murine leukemia virus

Project description:Murine leukemia virus overview

| PRJNA69631 | ENA

Ribosome profiling of the retrovirus murine leukemia virus

Project description:Ribosome profiling (Ribo-Seq) (maps positions of translating ribosomes on the transcriptome) and RNA-Seq (quantifies the transcriptome) analysis of Rattus norvegicus cells infected with Moloney Murine Leukemia Virus (Mo-MuLV).

2018-01-17 | E-MTAB-6231 | biostudies-arrayexpress

Human immunodeficiency virus 1

Project description:RNA-Seq of RNAs encapsidated by Human Immunodeficiency Virus 1

| PRJNA320293 | ENA

Ribosome profiling of the retrovirus murine leukemia virus

Project description:Ribosome profiling of the retrovirus murine leukemia virus

| PRJEB23562 | ENA

Assembly of cellular proteins with the HIV-1 genome into viral particles regulate virus production and infectivity

Project description:The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). However, the scope of these early host-virus interactions remain largely uncharecterised. To fill this gap, we developed in virion RNA interactome capture (ivRIC) to profile comprehensively and systematically the proteins that interact with the HIV-1 genomic (g)RNA inside viral particles. ivRIC identified 105 cellular RBPs within the encapsidated HIV-1 ribonucleoprotein, many of which are surprisingly nuclear. Analysis of the interactome of HIV-1 RBP Rev in infected cells revealed that most in virion incorporated (iv)RBPs likely associate with HIV-1 gRNA during its nuclear life. Functional assays showed that ivRBPs are important for HIV-1. For example, we found that PURA and PURB control viral gene expression and infectivity through interaction with critical sequences in the gRNA. In summary, the compositional analysis of the encapsidated ribonucleoprotein of HIV-1 uncovers host-virus interactions controlling virus infection.

2026-05-25 | PXD042829 | Pride

Bovine leukemia virus

Project description:Bovine leukemia virus genome sequencing and assembly

| PRJNA1363214 | ENA

ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF

Project description:Histone modifcations and CTCF binding at the c-myb locus were compared in cell lines with c-myb expressing, which are myeloblatic M1 cells and leukemia cells with virus integration, VS. M1 cells without c-myb expression induced by IL-6. Distribution of active histone marks at the c-myb gene and the upstream regions are associated with active c-myb transcription. The enrichment of all of these active histone marks decreased with differentiation-induced down-regulation of c-myb, but increased and spread in tumor cells. ChIP-on-chip from murine myeloid cell line M1 and virus-induced myeloid leukemia cell lines for H3K4me3, H3K9/14ac, H3K4me1, H3K27me3, H3K9me3 and CTCF

2012-09-01 | E-GEOD-34770 | biostudies-arrayexpress

Infection of RAW 264.7 cells by Murine Leukemia Virus-derived retroviral pseudotype expressing the envelope glycoprotein of EBOV is enhanced by immune serum and monoclonal antibodies

Project description:It has been shown that antibodies can enhance Ebola virus (EBOV) infection at sub-neutralizing concentrations. The effect of antibodies on the infection of murine cell line (RAW 264.7) with MLV-EBOV, a murine leukemia virus pseudotype expressing surface glycoprotein (GP) of EBOV and green fluorescent protein (GFP) has been studied. Moreover, regions of EBOV GP targeted by antibodies enhancing the infection have been investigated. Serum and monoclonal antibodies (mAbs) were obtained from mice inoculated with MLV-EBOV. Plasma from patients and humanized anti-EBOV GP mAbs were obtained. The proportion of GFP-positive cells was determined by immunocytofluorometry. Trypsin-digested EBOV GP was incubated in affinity columns prepared with mAbs. Eluted peptides were analyzed by high-resolution mass spectrometry. The infection of cells with MLV-EBOV was enhanced by immune mouse serum, human plasma and mAbs. The infection was the result of interactions between MLV-EBOV /antibody complexes and FcγRs. Regions of EBOV GP, located in GP1 core, furin cleavage site, N-terminal part of GP2, and HR1 and HR2 domains are target of antibodies able to enhance the infection. In conclusion, the RAW 264.7 cell line associated with MLV-EBOV can be used to study the enhancing activity of murine and human antibodies and may help to select antibodies or vaccine formulations that do not lead to enhancement of EBOV infection.

2026-01-26 | PXD066513 | Pride

Single-cell RNA transcriptome analysis of murine male and female forebrain tissue after recovery from West Nile virus encephalitis

Project description:Single-cell RNA-seq analysis of cortex and hippocampus tissue from murine males and females after recovery from West Niles virus encephalitis

2022-09-01 | GSE212199 | GEO

Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia

Project description:Despite the advanced understanding of disease mechanisms, the current therapeutic regimens fail to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply a murine model of mixed-lineage leukemia-rearranged AML to demonstrate that LSCs synthesize more proteins per hour compared with the bulk of leukemia. Using a genetic model that permits inducible and graded regulation of ribosomal subunit joining, we show that defective ribosome assembly leads to a significant survival advantage by selectively eradicating LSCs but not normal hematopoietic stem and progenitor cells. Finally, transcriptomic and proteomic analyses identify a rare subset of LSCs with immature stem cell signature and high ribosome content that underlies the resistance to defective ribosome assembly. Collectively, our study unveils a critical requirement of high protein synthesis rate for LSC function, highlighting ribosome assembly as a therapeutic target in AML.

2024-10-08 | PXD038318 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data