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Mus musculus

ABSTRACT: Gene expression profile of hepatic lincRNAs in male mouse liver using nuclear RNA-Seq

PROVIDER: PRJNA275764 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1810254_1.fastq.gz	Fastqsanger.gz
	SRR1810254_2.fastq.gz	Fastqsanger.gz
	SRR1810255_1.fastq.gz	Fastqsanger.gz
	SRR1810255_2.fastq.gz	Fastqsanger.gz
	SRR1810256_1.fastq.gz	Fastqsanger.gz

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Gene expression profile of hepatic lincRNAs in male mouse liver using nuclear RNA-Seq

Project description:Gene expression in adult male mouse liver was assayed by nuclear RNA-seq, as part of a study of hepatic lincRNAs.

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Project description:Sex differences in liver gene expression are dictated by sex-differences in circulating growth hormone (GH) profiles. Presently, the pituitary hormone dependence of mouse liver gene expression was investigated on a global scale to discover sex-specific early GH response genes that might contribute to sex-specific regulation of downstream GH targets and to ascertain whether intrinsic sex-differences characterize hepatic responses to plasma GH stimulation. RNA expression analysis using 41,000-feature microarrays revealed two distinct classes of sex-specific mouse liver genes: genes subject to positive regulation (class-I) and genes subject to negative regulation by pituitary hormones (class-II). Genes activated or repressed in hypophysectomized (Hypox) mouse liver within 30-90min of GH pulse treatment at a physiological dose were identified as direct targets of GH action (early response genes). Intrinsic sex-differences in the GH responsiveness of a subset of these early response genes were observed. Notably, 45 male-specific genes, including five encoding transcriptional regulators that may mediate downstream sex-specific transcriptional responses, were rapidly induced by GH (within 30min) in Hypox male but not Hypox female mouse liver. The early GH response genes were enriched in 29 male-specific targets of the transcription factor Mef2, whose activation in hepatic stellate cells is associated with liver fibrosis leading to hepatocellular carcinoma, a male-predominant disease. Thus, the rapid activation by GH pulses of certain sex-specific genes is modulated by intrinsic sex-specific factors, which may be associated with prior hormone exposure (epigenetic mechanisms) or genetic factors that are pituitary-independent, and could contribute to sex-differences in predisposition to liver cancer or other hepatic pathophysiologies.

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Project description:Gene expression in adult male and female mouse liver was analyzed based on nuclear RNA-seq, as part of a study on hepatic lincRNAs.

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Project description:Identification of sex-specific hepatic lincRNAs using nuclear RNA-Seq

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Project description:Gene expression profile of adult male mouse liver using total liver RNA-seq and nuclear liver RNA-Seq

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Project description:Gene expression in adult male and female mouse liver was assayed by RNA-seq, as part of a study on hepatic lincRNAs.

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Project description:Gene expression in adult female mouse liver was assayed by nuclear RNA-seq, as part of a study of hepatic lincRNAs.

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Gene expression profile of adult male mouse liver using total liver RNA-seq and nuclear liver RNA-Seq

Project description:Gene expression in male mouse liver was assayed by RNA-seq, as part of a study to study cellular compartmentalization of hepatic lincRNAs.

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