Project description:Single-nucleus RNA-seq of mouse mediobasal hypothalamus across dietary states (chow, fasting, refeeding, HFD), leptin IP injection, and Glp1rLeprKO genetic model. Identifies Lepr/Glp1r neurons as a uniquely leptin-sensitive population restraining AgRP-driven hyperphagia in diet-induced obesity.
Project description:Snord116 deletion mouse models recapitulate aspects of the Prader-Willi Syndrome. In this study, we examine the gene expression changes in the mediobasal hypothalamus for mice which have an adult onset deletion of Snord116 in the mediobasal hypothalamus.
