Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chlorocebus sabaeus

ABSTRACT: Understanding the role of Shoc2 protein in spatio-temporal regulation of extracellular signal-regulated kinase (ERK1/2) cascade

OTHER RELATED OMICS DATASETS IN: E-GEOD-67063

PROVIDER: PRJNA278844 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1919330.fastq.gz	Fastqsanger.gz
	SRR1919325.fastq.gz	Fastqsanger.gz
	SRR1919326.fastq.gz	Fastqsanger.gz
	SRR1919327.fastq.gz	Fastqsanger.gz
	SRR1919328.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer

Project description:The purpose of this study is to determine the safety of an extracellular signal regulated kinase (ERK1/2) inhibitor LY3214996 administered alone or in combination with other agents in participants with advanced cancer.

| 2221663 | ecrin-mdr-crc

LFQ of mouse brain in ischemic stroke

Project description:Ischemic disorders are the leading cause of death worldwide. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are part of the Raf/MEK/ERK1/2 cascade and are thought to affect the outcome of ischemic stroke. However, it is under debate whether activation or inhibition of ERK1/2 is beneficial. Therefore, this study aimed to investigate the impact of ERK1/2 after cerebral ischemia using transgenic mice with ubiquitous overexpression of ERK2 or of the Raf kinase inhibitor protein (RKIP), an inhibitor of the ERK1/2 signaling cascade.

2022-02-17 | PXD030067 | Pride

The genome of the vervet (Chlorocebus aethiops sabaeus).

Project description:We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for genetic investigations of simian immunodeficiency virus (SIV), for which it is the most abundant natural host species, and of a wide range of health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small numbers of their ancestors from West Africa during the colonial era. We use the reference to characterize the genomic relationship between vervets and other primates, the intra-generic phylogeny of vervet subspecies, and genome-wide structural variations of a pedigreed C. a. sabaeus population. Through comparative analyses with human and rhesus macaque, we characterize at high resolution the unique chromosomal fission events that differentiate the vervets and their close relatives from most other catarrhine primates, in whom karyotype is highly conserved. We also provide a summary of transposable elements and contrast these with the rhesus macaque and human. Analysis of sequenced genomes representing each of the main vervet subspecies supports previously hypothesized relationships between these populations, which range across most of sub-Saharan Africa, while uncovering high levels of genetic diversity within each. Sequence-based analyses of major histocompatibility complex (MHC) polymorphisms reveal extremely low diversity in Caribbean C. a. sabaeus vervets, compared to vervets from putatively ancestral West African regions. In the C. a. sabaeus research population, we discover the first structural variations that are, in some cases, predicted to have a deleterious effect; future studies will determine the phenotypic impact of these variations.

| S-EPMC4665013 | biostudies-literature

The transcription of long non-coding RNAs is regulated by EGF in MCF10A cell line

Project description:Whilst the biological function of many lncRNAs remains unknown, recent evidence has suggested that lncRNAs may be important regulators of cellular growth, differentiation and may play a significant role in cancer. Epidermal growth factor (EGF) an activator of the ERK1/2 signalling cascade is an important spatio-temporal regulator of transcription and, ultimately, of cellular growth and movement. In order to identify lncRNAs regulated by EGF signalling, we sequenced nuclear RNA in the presence or absence of EGF stimulation.

2017-09-25 | E-MTAB-5370 | biostudies-arrayexpress

Standardized full-field electroretinography in the Green Monkey (Chlorocebus sabaeus).

Project description:Full-field electroretinography is an objective measure of retinal function, serving as an important diagnostic clinical tool in ophthalmology for evaluating the integrity of the retina. Given the similarity between the anatomy and physiology of the human and Green Monkey eyes, this species has increasingly become a favorable non-human primate model for assessing ocular defects in humans. To test this model, we obtained full-field electroretinographic recordings (ERG) and normal values for standard responses required by the International Society for Clinical Electrophysiology of Vision (ISCEV). Photopic and scotopic ERG recordings were obtained by full-field stimulation over a range of 6 log units of intensity in dark-adapted or light-adapted eyes of adult Green Monkeys (Chlorocebus sabaeus). Intensity, duration, and interval of light stimuli were varied separately. Reproducible values of amplitude and latency were obtained for the a- and b-waves, under well-controlled adaptation and stimulus conditions; the i-wave was also easily identifiable and separated from the a-b-wave complex in the photopic ERG. The recordings obtained in the healthy Green Monkey matched very well with those in humans and other non-human primate species (Macaca mulatta and Macaca fascicularis). These results validate the Green Monkey as an excellent non-human primate model, with potential to serve for testing retinal function following various manipulations such as visual deprivation or drug evaluation.

| S-EPMC4216091 | biostudies-literature

Genome-wide analysis of short-term transcriptional responses in thrombin-stimulated vascular smooth muscle cells

Project description:The strength and duration of extracellular signal-regulated kinases 1/2 (ERK1/2) phosphorylation can define the phenotypic outcome of cells. Stimualtion of the proteinase-activated receptor (Par) triggers a Gi-dependent long-lasting transactivation of the epidermal growth factor receptor and subsequent ERK1/2 phosphorylation. To understand the mechnaisms underlying this signaling cascade, microarray analysis was performed in vascular smooth muscle cells.

2009-04-28 | GSE15841 | GEO

Transcription profiling of rat thrombin-stimulated vascular smooth muscle cells

2009-05-02 | E-GEOD-15841 | biostudies-arrayexpress

Chlorocebus sabaeus

Project description:Genome Sequencing of Chlorocebus aethiops sabaeus

| PRJNA168527 | ENA

Chlorocebus sabaeus

Project description:Whole transcriptome profiles of different brain regions from a Chlorocebus sabaeus model of Parkinson's disease with and without human parthenogenetic stem cell derived neural stem cell transplantation.

| PRJNA314354 | ENA

Chlorocebus sabaeus

Project description:Identification of brain transcriptional variability reproduced in peripheral blood: an approach for mapping brain eQTLs

| PRJNA115831 | ENA