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Mus musculus

ABSTRACT: Redefining the role of eIF4E dose in development, cancer, and protein synthesis

OTHER RELATED OMICS DATASETS IN: E-GEOD-68238

PROVIDER: PRJNA282121 | ENA |

REPOSITORIES: ENA

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E-GEOD-68238

Project description:Redefining the role of eIF4E dose in development, cancer, and protein synthesis

2015-09-18 | E-GEOD-68238 | ExpressionAtlas

Redefining the role of eIF4E dose in development, cancer, and protein synthesis

Project description:eIF4E, the major cap-binding protein, has long been considered limiting for translating the mammalian genome. However, the requirement for eIF4E dose at an organismal level remains unexplored. By generating an Eif4e haploinsufficient mouse, we surprisingly found that 50% reduction in eIF4E, while compatible with normal development and global protein synthesis, significantly impeded cellular transformation and tumorigenesis. Genome-wide translational profiling uncovered a translational program induced by oncogenic transformation and revealed a critical role for eIF4E dose specifically in translating a network of mRNAs enriched for a unique 5’UTR signature. In particular, we demonstrate that eIF4E dose is essential for translating mRNAs regulating reactive oxygen species (ROS) that fuel transformation and cancer cell survival in vivo. Therefore, mammalian cells have evolved surplus eIF4E levels that cancer cells hijack to drive a translational program supporting tumorigenesis

2015-07-01 | GSE68238 | GEO

Redefining the role of eIF4E dose in development, cancer, and protein synthesis

2015-07-01 | E-GEOD-68238 | biostudies-arrayexpress