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Caenorhabditis elegans

ABSTRACT: Recruitment of RNA Polymerase II by the pioneer transcription factor PHA-4

PROVIDER: PRJNA282374 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1998060.fastq.gz	Fastqsanger.gz
	SRR1998061.fastq.gz	Fastqsanger.gz
	SRR1998062_1.fastq.gz	Fastqsanger.gz
	SRR1998062_2.fastq.gz	Fastqsanger.gz
	SRR1998063_1.fastq.gz	Fastqsanger.gz

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Project description:Identification of Transcription Factor PHA-4::GFP Binding Regions in L3

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [ChIP-seq]

Project description:Immediately after fertilization the genome is transcriptionally quiescent. Maternally encoded pioneer transcription factors reprogram the chromatin state and facilitate the transcription of the zygotic genome. In Drosophila, transcription is initiated by the pioneer factor Zelda. While Zelda-occupied sites are enriched with histone acetylation, a post-translational mark associated with active cis-regulatory regions, the functional relationship between Zelda and histone acetylation in zygotic genome activation remained unclear. We show that Zelda-mediated recruitment of the histone acetyltransferase CBP is essential for zygotic transcription and embryonic development. CBP catalytic activity is necessary for release of RNA Polymerase II (Pol II) into transcription elongation. However, CBP largely activates zygotic transcription independent of acetylation through Pol II recruitment. Neither acetylation nor CBP are required for the pioneering function of Zelda. Our data suggest that pioneer factor-mediated recruitment of CBP is a conserved mechanism required to activate zygotic transcription but that this role is separable from the function of pioneer factors in restructuring chromatin accessibility.

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [ATAC-seq]

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [CUT&Tag]

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [RNA-Seq]

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [PRO-Seq]

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Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation [RNA-seq]

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Caenorhabditis elegans

Project description:The landscape of RNA polymerase II transcription initiation in C. elegans reveals a novel regulatory architecture

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Caenorhabditis elegans

Project description:PHA-4 organogenesis

| PRJNA93821 | ENA

RNA polymerase occupancy at embryonic stage and starved L1 stage in pha-4 transgenic worms

Project description:We acquired RNA Polymerase II (POL II) binding profiles at embyonic and starved L1 stages in pha-4 transgenic worms. Transcription factor gene pha-4 was tagged with GFP and their expression examined throughout the C. elegans life cycle. The POL II occupancy were determined using chromatin immunoprecipitation with anti-POL II antibodies followed by illumina high-throughput sequencing (ChIP-seq). For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf

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