Project description:<p>Type 1 Diabetes Genetics Consortium (T1DGC) was formed to address issues of limited sample size and consistency of phenotyping that had limited genetic investigations on risk of type 1 diabetes (T1D). The T1DGC first collected affected sib pair (ASP) families from four geographic networks (Asia-Pacific, Europe, North America, United Kingdom). In addition, T1D parent-offspring trios as well as cases and controls were ascertained from existing and de novo collections. For T1D, the genome-wide association study (GWAS) design has been successful at detecting ~50 loci that contribute disease risk. However, in the case of T1D as well as almost all other traits, the sum of these loci does not fully explain the heritability estimated from familial studies. One possibility for the undiscovered contribution to familial aggregation is that additional variants exist but have not yet been found because they have not effectively been targeted by the GWAS design. In this study, we focus on a specific class of large deletions/duplications -- copy number variants (CNVs) - and particularly to the subset of these loci that mutate rapidly, are not tagged by SNPs, and are highly polymorphic. The T1DGC assembled 2,601 T1D ASP families and 69 Parent-T1D offspring trios, that were eligible for this study. All samples included in this series have reported or self-declared European ancestry. All DNA samples were collected after approval from relevant institutional research ethics committees. Importantly, the source of DNA for CNV evaluation was uniform within a family (either all from PBMC or from EBV-transformed cell lines). We use a family based design that was optimized to capture these previously untested variants. We then perform a genome-wide scan to assess their contribution to T1D.</p>

| phs000910 | dbGaP

Alzheimer's Disease Genetics Consortium

Project description:Alzheimer's Disease Genetics Consortium

| PRJNA155369 | ENA

Homo sapiens

Project description:Type 1 Diabetes Genetics Consortium (T1DGC) GWAS

| PRJNA75445 | ENA

Homo sapiens

Project description:Type 1 Diabetes Genetics Consortium (T1DGC) GWAS

| PRJNA75447 | ENA

Type 1 Diabetes Genetics Consortium: A multi-ancestry, genome-wide association study of type 1 diabetes

Project description:Type 1 Diabetes Genetics Consortium: A multi-ancestry, genome-wide association study of type 1 diabetes