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Caenorhabditis elegans

ABSTRACT: Transcriptional profile of C. elegans following RNAi of elt-2 [L4 stage]

PROVIDER: PRJNA285044 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2040653.fastq.gz	Fastqsanger.gz
	SRR2040654.fastq.gz	Fastqsanger.gz
	SRR2040655.fastq.gz	Fastqsanger.gz
	SRR2040656.fastq.gz	Fastqsanger.gz
	SRR2040657.fastq.gz	Fastqsanger.gz

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Sequencing of Caenorhabditis elegans deletion mutants treated with RNAi

Project description:Comparison of gene expression profiles from C. elegans mutant strain CF1038 treated with L4440 and K02A4.1 RNAi and C. elegans mutant strain TU3311 treated with L4440 and B0412.2 RNAi for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110840 | GEO

Transcriptional profile of C. elegans following RNAi of elt-2

Project description:Transcriptional profile of C. elegans following RNAi of elt-2

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Sequencing of Caenorhabditis elegans wildtype strain (N2) treated with T25B9.1 RNAi for 5 days after L4 larvae stage.

Project description:Comparison of gene expression profiles from C. elegans wildtype strain (N2) treated with L4440 and T25B9.1 RNAi for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (ww.jenage.de)

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Project description:Transcriptional profiling of C. elegans aptf-1(gk7954) mutant in L4 sleep stage.

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Sequencing of Caenorhabditis elegans wildtype strain (N2) treated with T25B9.1 RNAi for 2 and 5 days after L4 larvae stage.

Project description:Comparison of gene expression profiles from C. elegans wildtype strain (N2) treated with L4440 and T25B9.1 RNAi for 2 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Genome-wide characterization of the Caenorhabditis elegans intestine GATA transcription factor ELT-2

Project description:ELT-2 is the major transcription factor required for Caenorhabditis elegans intestinal development. It initiates in embryos to promote development then persists after hatching through larval and adult stages. Though the sites of ELT-2 binding are characterized and the transcriptional changes that result from ELT-2 depletion are described, a major missing piece has been the lack of an intestine-specific transcriptome profile over developmental time. We generated this dataset by Fluorescence Activated Cell Sorting (FACS) intestine cells at distinct developmental stages. We analyzed this dataset in conjunction with previously conducted ELT-2 studies to evaluate ELT-2’s role in directing the intestinal regulatory network through development. We found that only 33% of intestine-enriched genes in the embryo were direct targets of ELT-2 but that number increased to 75% by the L3 stage. This suggests additional transcription factors promote intestinal transcription especially in the embryo. Furthermore, only half of ELT-2’s direct target genes were dependent on ELT-2 for their proper expression levels, and an equal proportion of those responded to elt-2 depletion with over-expression as with under-expression. That is, ELT-2 can either activate or repress direct target genes. Indeed, we observed that ELT-2 repressed its own promoter, implicating new models for its autoregulation. Together, our results illustrate that ELT-2 impacts roughly 20 – 50% of intestine-specific genes, that ELT-2 both positively and negatively controls its direct targets, and that our current model of the intestinal regulatory network is incomplete as the factors responsible for directing the expression of many intestinal genes remain unknown.

2023-05-04 | GSE214581 | GEO

Sequencing of Caenorhabditis elegans overexpression mutants.

Project description:Comparison of gene expression profiles from C. elegans mutant strains (MIR73, MIR75 or MIR77) overexpressing genes involved in proline metabolism (B0513.5 or T22H6.2) with wildtype strain (N2) at 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110842 | GEO

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