Dataset Information

Rickettsia felis

ABSTRACT: RNA sequencing of Rickettsia felis str. LSU infecting Ctenocephalides felis and Rickettsia felis str. LSU-Lb infecting Liposcelis bostrychophila

PROVIDER: PRJNA285354 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2049306.fastq.gz	Fastqsanger.gz
	SRR2051064.fastq.gz	Fastqsanger.gz
	SRR2051066.fastq.gz	Fastqsanger.gz
	SRR2051067.fastq.gz	Fastqsanger.gz
	SRR2051068.fastq.gz	Fastqsanger.gz

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Project description:The role of domestic and peridomestic animals in vector-borne diseases is very important as they share a common environment with people having the potential to extend the network of pathogen transmission to humans. The most significant vector-borne infectious diseases that are shared by man, domestic and peridomestic animals are leishmaniosis, borreliosis, bartonellosis, ehrlichiosis, rickettsiosis and anaplasmosis with fleas acting as main vectors in the transmission of some of these diseases. Flea-borne diseases which are relevant in Europe include plague (caused by Yersinia pestis), murine typhus (caused by Rickettsia typhi), flea-borne spotted fever (Rickettsia felis), and cat scratch disease (Bartonella henselae). In the present study, mNGS was applied to detect and understand the composition of the microbial communities of five different species of fleas (Archaeopsylla erinacei, Ctenocephalides felis, Spilopsyllus cuniculi, Pulex irritans and Ctenocephalides canis) collected on dogs, cats and hedgehogs from Andalusia (Spain) to know the prevalence of pathogenic bacteria among synanthropic fleas. Based on our results, we could conclude that Pulicidae family encompassed those flea species with a close contact with humans and therefore more involved in the potential transmission of infectious diseases. The higher relative abundance of the Phylum Pseudomanadota was mainly due to the presence of the endosymbiont Wolbachia, as well as to notice a high relative abundance of both genera Rickettsia and Bartonella in all flea species. For the first time, we detected Babesia sp. in all species tested, especially with higher abundance in S. cuniculi collected from cats emphasizing the need for further investigation into its potential implications as vectors. Our results also demonstrate that the microbiota composition of fleas is largely influenced by the host they parasitize. Lastly, statistical analyses of microbiota allowed for the ecological separation of flea species, with individuals from these five species clustering distinctly each other.

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Rickettsia felis

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