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MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells

ABSTRACT: MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells

PROVIDER: PRJNA287689 | ENA |

REPOSITORIES: ENA

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MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells.

Project description:Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS.

| S-EPMC4618452 | biostudies-literature

MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-08-01 | GSE70131 | GEO

MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-01 | E-GEOD-70131 | biostudies-arrayexpress

Contribution of molecular actors from somatic origin to oocyte developmental competence acquisition, lessons from evolution

Project description:This SuperSeries is composed of the following subset Series: GSE36602: Transcriptional profiling of somatic cells differentiation throughout oocyte competence acquisition in rainbow trout ovarian follicles. GSE36603: Transcriptional profiling of somatic cells differentiation throughout oocyte competence acquisition in the xenopus ovarian follicles. GSE36604: Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the murine ovarian follicles. GSE36605: Transcriptional profiling of cumulus cells differentiation throughout oocyte competence acquisition in the bovine ovarian follicles. Refer to individual Series

2012-10-14 | E-GEOD-36617 | biostudies-arrayexpress

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e16]

Project description:Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e16]

| PRJNA1254748 | ENA

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [ATACseq_e16]

Project description:Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [ATACseq_e16]

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Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e17]

Project description:Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e17]

| PRJNA1254749 | ENA

Cumulus cell gene expression associated with pre-ovulatory acquisition of developmental competence in bovine oocytes

Project description:This study investigated the cumulus cell (CC) transcriptomic changes during the oocyte developmental competence acquisition period.

2016-04-01 | GSE79760 | GEO

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e17]

Project description:The remarkable cell diversity of multicellular organisms relies on the ability of multipotent progenitor cells to generate distinct cell types at the right times and locations during embryogenesis. A key question is how progenitors establish competence to respond to the different environmental signals required to produce specific cell types at critical developmental timepoints. We addressed this in the mouse developing forebrain, where neural progenitor cells must switch from producing neurons to making oligodendrocytes in response to increased Sonic Hedgehog (SHH) signaling during late embryogenesis. We show that progenitor responses to SHH are regulated by Notch signaling, thus permitting proper timing of the neuron-oligodendrocyte switch. Notch activity epigenetically primes genes associated with the oligodendrocyte lineage and SHH pathway, enabling amplified transcriptional responses to endogenous SHH and robust oligodendrogenesis. These results reveal a critical role for Notch in facilitating progenitor competence states and influencing cell fate transitions at the epigenetic level.

2025-07-09 | GSE295476 | GEO

Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence [RNAseq_e16]

2025-07-09 | GSE295475 | GEO