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Escherichia coli REL606

ABSTRACT: Mutation rate inferred from synonymous substitutions in a long-term evolution experiment with Escherichia coli

PROVIDER: PRJNA288762 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR2085290.fastq.gz	Fastqsanger.gz
	SRR2086040.fastq.gz	Fastqsanger.gz
	SRR2086070.fastq.gz	Fastqsanger.gz
	SRR2086150.fastq.gz	Fastqsanger.gz
	SRR2086041.fastq.gz	Fastqsanger.gz

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Escherichia coli REL606

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The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae

2012-02-02 | GSE35440 | GEO

The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae

Project description:microarray experiment to test the gene expression in long term lines of mutator and non-mutator yeast. Here we use an experimental evolution approach to investigate the conditions required for evolution of a reduction in mutation rate and the mechanisms by which populations tolerate the accumulation of deleterious mutations. We find that after ~6700 generations four out of eight experimental mutator lines had evolved a decreased mutation rate. 2 condition experiment, derived experimental evolution strains compared to their ancestor strain. We compared the expression profile of one of the mutator lines (m8) after 6700 generations with its mutator ancestor, and as a control, an evolved non mutator after 6700 generations was compared to to its non-mutator ancestor. In order to prepare cells for expression microarray, glass tubes containing 3 ml of YPD were inoculated from overnight cultures, and grown until the OD600 was approximately 0.3.

2012-02-02 | E-GEOD-35440 | biostudies-arrayexpress

Simulated Microgravity Triggers a Membrane Adaptation to Stress in E. coli REL606

Project description:Investigating the evolution of Escherichia coli in microgravity offers valuable insights into microbial adaptation to extreme environments. Here the effects of simulated microgravity (SµG) on gene expression of E. coli REL606, a strain evolved terrestrially for 35 years is explored. We evaluated the transcriptomic changes for glucose-limited and glucose-replete conditions over 24 hours which illustrate that SµG increased the expression of stress response and cell membrane-related genes, particularly under glucose-limited conditions. A machine learning model predicted that glucose-limited SµG impacts the cellular membrane, while glucose-replete SµG also inhibits protein synthesis at stationary phase. These findings highlight the transcriptomic and physiological adaptations of E. coli to short term microgravity, offering a foundation for future research into the long-term effects of space conditions on bacterial evolution.

2025-05-13 | GSE284563 | GEO

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