Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA292575 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:There is an urgent need for early detection of Pancreatic ductal adenocarcinoma (PDAC). Due to high stability and tight relationship with tumor genesis and development, miRNA has been considered as a type of potential biomarkers for PDAC detection and surveillance. However, up to now, the common miRNA panel for PDAC detection is still undetermined. In order to reveal the differential miRNA expression profiles between PDAC patients(P group), chronic pancreatitis patients(C group) and healthy persons(H group), plasma samples were collected from threegroups, further the genome wide small RNA expression profiling was performed.
2021-05-22 | GSE114778 | GEO
Project description:Currently, the majority of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) present with locally invasive and/or metastatic disease, resulting in five-year survival of less than 5%. The development of an early diagnostic test is, therefore, expected to significantly impact the patient’s prognosis. In this feasibility study, we demonstrate for the first time the utility of miRNA biomarkers for non-invasive, early detection of PDAC in urine specimens.
2016-01-28 | GSE71962 | GEO
Project description:Multiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
| PRJNA111171 | ENA
Project description:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types, partly because it is frequently identified at an advanced stage, when surgery is no longer feasible. Therefore, early detection using minimally invasive methods such as blood tests may improve outcomes. However, studies to discover molecular signatures for the early detection of PDAC using blood tests have only been marginally successful. In the current study, a quantitative glycoproteomic approach via data-independent acquisition mass spectrometry (DIA-MS) was utilized to detect glycoproteins in 29 patient-matched PDAC tissues and sera. Total of 892 glycopeptides originated from 141 glycoproteins had PDAC associated changes beyond normal variation. We further evaluated the specificity of these serum detectable glycoproteins by comparing their abundance in 53 independent PDAC patient sera and 65 cancer-free controls. The PDAC tissue-associated glycoproteins we have identified represent an inventory of serum detectable PDAC glycoproteins as candidate biomarkers that can be potentially used for the detection of PDAC using blood tests.
2023-12-19 | PXD039273 | Pride
Project description:Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Late presentation of disease at the time of diagnosis is one of the major reasons for dismal prognostic outcomes for PDAC patients. Currently, there is a lack of clinical biomarkers which can be used to diagnose PDAC patients at an early resectable stage. This study performed proteomic mass spectrometry to identify novel blood-based biomarkers for early diagnosis of PDAC.
2024-03-05 | PXD046438 | Pride
Project description:Combinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_miRNA
| PRJNA176699 | ENA
Project description:Combinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_mRNA
| PRJNA176698 | ENA
Project description:MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with premalignant lesions. We wished to identify miRNA expression profiles in pancreatic cystic tumors with low malignant potential (serous microcystic adenomas) and high malignant potential (mucinous cystadenoma and intraductal papillary mucinous neoplasm (IPMN)) and compare these to PDAC and carcinoma-ex-IPMN (CEI). n= 20 samples Benign Pancreatic Cystic Tumour (n=7 Microcystic, n= 6 Mucinous, n= 7 IPMN) were compared with n= 9 samples of carcinoma ex IPMN and n= 14 samples of pancreatic cancer (adenocarcinoma) for known homo sapiens miRNAs (mirbase 13).
2011-05-18 | E-GEOD-29352 | biostudies-arrayexpress
Project description:Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and unmet needs for clinical biomarkers. Extracellular vesicles (EVs) contain diverse biomolecules, including several kinds of small RNAs (smRNAs). We investigated EV-containing smRNAs (EV-smRNAs) as novel PDAC biomarkers. SmRNA-seq showed that the total count of EV-smRNAs was remarkably downregulated in PDAC when it was compared with normal controls. Among them, the expression of microRNAs (miRNAs) including miR-125a-5p, miR-30e-5p, miR-16-2-3p, miR-98-5p and let-7 family were considerably attenuated in PDAC, and especially decreased miR-142-5p and let-7f-5p were significantly related to the early stage of PDAC. Also, upregulated long non-coding RNAs (lncRNAs) such as DDX59-AS1, SNHG25, LDLRAD4-AS1, and LYPLAL1-DT, and downregulated miRNAs such as miR-766-3p, miR-148b-3p and miR-337-3p were associated with metastatic PDAC. Considering the prognosis, lncRNA CARS1-AS1 and miRNA miR-142-5p were upregulated in patients with better responses to treatment. Moreover, we found a set of miRNA-lncRNA-target gene candidates, consisting of miRNA let-7c-5p and miR-98-5p, lncRNA OLMALINC, and target genes BACH1 and CCND1. In PDAC cell lines and PDAC organoids, they played a role in mainly cell migration during PDAC progression. We suggested some potential EV-smRNA biomarkers involved in PDAC development, metastasis and prognosis, and also underlined mechanistic insights into PDAC progression.
2025-12-02 | GSE268771 | GEO
Project description:To further development of our lncRNA and mRNA expression approach to pancreatic ductal adenocarcinoma(PDAC), we have employed lncRNA and mRNA microarray expression profiling as a discovery platform to identify lncRNA and mRNA expression in pancreatic ductal adenocarcinoma.Human pancreatic ductal adenocarcinoma tissues and normal pancreatic tissues from PDAC donors and other duodenum diseases donors. analyze mRNA and lncRNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform
2014-11-18 | E-GEOD-57144 | biostudies-arrayexpress