Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Saccharomyces cerevisiae

ABSTRACT: Termination of replication stress signaling via concerted action of the Slx4-Rtt107 scaffolds and the PP4 phosphatase

PROVIDER: PRJNA293857 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2188110.fastq.gz	Fastqsanger.gz
	SRR2188111.fastq.gz	Fastqsanger.gz
	SRR2188112.fastq.gz	Fastqsanger.gz
	SRR2188113.fastq.gz	Fastqsanger.gz
	SRR2188114.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Saccharomyces cerevisiae

Project description:Assembly of Slx4 Signaling Complexes Behind Stalled Replication Forks

| PRJNA262566 | ENA

Saccharomyces cerevisiae W303

Project description:Concerted activities of Mcm4, Sld3, and Dbf4 in DNA replication

| PRJNA290783 | ENA

Saccharomyces cerevisiae

Project description:RNA Polymerase II CTD phosphatase Rtr1 restricts noncoding transcript termination by Nrd1

| PRJNA345490 | ENA

Saccharomyces cerevisiae

Project description:Quantitative, genome-wide analysis of eukaryotic replication initiation and termination

| PRJNA174633 | ENA

Saccharomyces cerevisiae

Project description:High-resolution genome replication profiles, modeling and single-cell imaging define the stochastic nature of replication initiation and termination

| PRJNA210660 | ENA

Saccharomyces cerevisiae

Project description:Replication termination is mediated by Top2 and occurs at genomic loci containing pausing elements

| PRJNA120567 | ENA

Saccharomyces cerevisiae BY4741

Project description:Rtt109 effect on replication speed via histone acetylation

| PRJNA631463 | ENA

Saccharomyces cerevisiae

Project description:Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

| PRJNA141229 | ENA

Expression data from Saccharomyces cerevisiae strains carrying the rna14-1 or the rna15-1 allele

Project description:In the yeast Saccharomyces cerevisiae, cleavage factor I (CFI) and cleavage and polyadenylation factor (CPF) build the core of the transcription termination machinery. CFI comprises the Rna14, Rna15, Pcf11, and Clp1 proteins, as well as the associated Hrp5 RNA-binding protein. We found that CFI participates in the DNA damage response and that rna14-1 shows synthetic growth defects with mutants of different repair pathways, including homologous recombination, non-homologous end joining, post replicative repair, mismatch repair, and nucleotide excision repair, implicating that impaired RNAPII termination and 3’-end processing decreases the cellular tolerance for DNA damage. Beyond replication progression defects, we found that bypass of the G1/S checkpoint in rna14-1 cells leads to synthetic sickness, accumulation of phosphorylated H2A, as well as increase in Rad52-foci and in recombination. Our data provide evidence that CFI dysfunction impairs RNAPII turnover, leading to replication hindrance and lower tolerance to exogenous DNA damage. These findings underscore the importance of coordination between transcription termination, DNA repair and replication in the maintenance of genomic stability.

2014-03-31 | GSE50947 | GEO

Saccharomyces cerevisiae

Project description:Slx4 and Rtt107 control checkpoint signaling and DNA resection at double-strand breaks

| PRJNA288886 | ENA