Plasmodium berghei
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA293968 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Transcriptional profiling of gametocyte non-producer lines in Plasmodium berghei Transcriptome of gametocyte non producer lines (natural and genetic KO) and parental (820) lines. The aim of the study was to identify key genes involved in the decision to commit to gametocytogenesis in Plasmodium berghei. These microarrays compare naturally selected lines that do not produce gametocytes, and the parental line and additionally a genetic knock out of AP2-G PBANKA_143750. Data published Sinha, Hughes, et, al Nature tbc. 2- colour microarray comparing to common background pool (containing all life cycle stages). Replicates of different life cycle stages of gametocyte non-producer lines and wild tye (WT) parental control lines
2013-12-13 | E-GEOD-53246 | biostudies-arrayexpress
Project description:Global gene expression profiling of P. berghei liver stages at 36h from WT and Pb SSPELD KO parasites to investigate the changes in RNA expression levels in Pb SSPELD parasites.
2016-09-01 | GSE72399 | GEO
Project description:Malaria sporozoites, the form transmitted by mosquitoes, are quiescent while in the insect salivary glands. It is only after the sporozoites are deposited in the hostâs skin, migrate to the liver and infect hepatocytes that the parasites continue the life cycle. We show that the sporozoite latency is an active process that requires phosphorylation of the eukaryotic initiation factor-2α (eIF2α) by a sporozoite-specific kinase. Inactivation of the kinase gene leads to an overall enhancement of protein synthesis including of silenced liver stage proteins, and inhibits transmission of malaria. Specific inhibition of the eIF2α phosphatase by salubrinal has the opposite effect. Thus, to prevent premature transformation into liver stages, Plasmodium sporozoites exploit the same mechanism that regulates stress responses in mammalian cells. 4 samples overall, 2 wt and 2 KO (PbeIK2 knockout) samples
2010-05-16 | E-GEOD-16259 | biostudies-arrayexpress
Project description:Malaria sporozoites, the form transmitted by mosquitoes, are quiescent while in the insect salivary glands. It is only after the sporozoites are deposited in the host’s skin, migrate to the liver and infect hepatocytes that the parasites continue the life cycle. We show that the sporozoite latency is an active process that requires phosphorylation of the eukaryotic initiation factor-2α (eIF2α) by a sporozoite-specific kinase. Inactivation of the kinase gene leads to an overall enhancement of protein synthesis including of silenced liver stage proteins, and inhibits transmission of malaria. Specific inhibition of the eIF2α phosphatase by salubrinal has the opposite effect. Thus, to prevent premature transformation into liver stages, Plasmodium sporozoites exploit the same mechanism that regulates stress responses in mammalian cells.
2009-07-01 | GSE16259 | GEO
Project description:Previously published data indicated that PgCHT2 forms a high molecular weight (HMW), reduction-sensitive complex; data suggested that the binding partner is the ookinete-produced von Willebrand A-domain-containing protein, WARP. To test the hypothesis that transgenic P.berghei ookinete-produced PfCHT1 could form a high molecular homo-multimer or, alternatively, could interact with P. berghei ookinete-produced proteins to produce a HMW hetero-multimer, we created a chimeric P. berghei parasites expressing PfCHT1 to replace PbCHT1, allowing production of large numbers of PfCHT1-expressing ookinetes.Mass spectrometry analysis was carried out on the chitin affinity pulled down proteins from the Pb-PfCHT1(r) ookinete culture supernatant.
2021-09-09 | PXD021970 | Pride
Project description:Transcriptional profiling of gametocyte non-producer lines in Plasmodium berghei Transcriptome of gametocyte non producer lines (natural and genetic KO) and parental (820) lines. The aim of the study was to identify key genes involved in the decision to commit to gametocytogenesis in Plasmodium berghei. These microarrays compare naturally selected lines that do not produce gametocytes, and the parental line and additionally a genetic knock out of AP2-G PBANKA_143750. Data published Sinha, Hughes, et, al Nature tbc.
2013-12-13 | GSE53246 | GEO
Project description:Transcription profiling by array of liver from Taf10 knock out mice
2014-07-03 | E-MEXP-3442 | ExpressionAtlas
Project description:Transcription profiling by array of liver-specific Hnf4alpha knock-out mice
2014-07-03 | E-MEXP-1733 | ExpressionAtlas
Project description:Transcription profiling by array of liver from Ercc1 knock-out mice
2014-07-03 | E-MEXP-834 | ExpressionAtlas
Project description:Transcription profiling by array of liver from KLF10 knock out mice
2014-07-03 | E-MEXP-2089 | ExpressionAtlas